Springer Nature
Pharmaceutical Chemistry Journal
,  volume 47 ,  issue 9 ,  pages 459-463

Synthesis and Anti-HIV-1 activity of 1-[ω-(Phenoxy)Alkyl and -Alkenyl]Uracil derivatives

Publication type: Journal Article
Publication date: 2013-12-11
Springer Nature
scimago Q4
wos Q4
SJR: 0.219
CiteScore: 1.4
Impact factor: 1.0
ISSN: 0091150X, 15739031
Drug Discovery
Pharmacology
Abstract
1-[ω-(Phenoxy)alkyl and -alkenyl]uracil derivatives were synthesized via condensation of equimolar amounts of 2,4-bis(trimethylsilyloxy)pyrimidine and 1-halo-ω-(phenoxy)alkane or -alkene in order to discover new non-nucleoside inhibitors of HIV-1 reverse transcriptase. Their anti-HIV-1 activity was studied in CEM-cell culture and against HIV-1 reverse transcriptase. It was found that several compounds exhibited marked activity.
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GOST Copy
Paramonova M. P. et al. Synthesis and Anti-HIV-1 activity of 1-[ω-(Phenoxy)Alkyl and -Alkenyl]Uracil derivatives // Pharmaceutical Chemistry Journal. 2013. Vol. 47. No. 9. pp. 459-463.
GOST all authors (up to 50) Copy
Paramonova M. P., Babkov D. A., Valuev Elliston V. T., A.V. I., Kochetkov S. N., Pannecouque C., Ozerov A., Balzarini J., Novikov M. Synthesis and Anti-HIV-1 activity of 1-[ω-(Phenoxy)Alkyl and -Alkenyl]Uracil derivatives // Pharmaceutical Chemistry Journal. 2013. Vol. 47. No. 9. pp. 459-463.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1007/s11094-013-0980-8
UR - https://doi.org/10.1007/s11094-013-0980-8
TI - Synthesis and Anti-HIV-1 activity of 1-[ω-(Phenoxy)Alkyl and -Alkenyl]Uracil derivatives
T2 - Pharmaceutical Chemistry Journal
AU - Paramonova, M P
AU - Babkov, D A
AU - Valuev Elliston, V T
AU - A.V., Ivanov
AU - Kochetkov, S. N.
AU - Pannecouque, C
AU - Ozerov, A.A.
AU - Balzarini, J.
AU - Novikov, M.S.
PY - 2013
DA - 2013/12/11
PB - Springer Nature
SP - 459-463
IS - 9
VL - 47
SN - 0091-150X
SN - 1573-9031
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2013_Paramonova,
author = {M P Paramonova and D A Babkov and V T Valuev Elliston and Ivanov A.V. and S. N. Kochetkov and C Pannecouque and A.A. Ozerov and J. Balzarini and M.S. Novikov},
title = {Synthesis and Anti-HIV-1 activity of 1-[ω-(Phenoxy)Alkyl and -Alkenyl]Uracil derivatives},
journal = {Pharmaceutical Chemistry Journal},
year = {2013},
volume = {47},
publisher = {Springer Nature},
month = {dec},
url = {https://doi.org/10.1007/s11094-013-0980-8},
number = {9},
pages = {459--463},
doi = {10.1007/s11094-013-0980-8}
}
MLA
Cite this
MLA Copy
Paramonova, M. P., et al. “Synthesis and Anti-HIV-1 activity of 1-[ω-(Phenoxy)Alkyl and -Alkenyl]Uracil derivatives.” Pharmaceutical Chemistry Journal, vol. 47, no. 9, Dec. 2013, pp. 459-463. https://doi.org/10.1007/s11094-013-0980-8.