Springer Nature
Pharmaceutical Chemistry Journal
,  том 47 ,  издание 9 ,  страницы 459-463

Synthesis and Anti-HIV-1 activity of 1-[ω-(Phenoxy)Alkyl and -Alkenyl]Uracil derivatives

Тип публикации: Journal Article
Дата публикации: 2013-12-11
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SJR: 0.219
CiteScore: 1.4
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ISSN: 0091150X, 15739031
Drug Discovery
Pharmacology
Краткое описание
1-[ω-(Phenoxy)alkyl and -alkenyl]uracil derivatives were synthesized via condensation of equimolar amounts of 2,4-bis(trimethylsilyloxy)pyrimidine and 1-halo-ω-(phenoxy)alkane or -alkene in order to discover new non-nucleoside inhibitors of HIV-1 reverse transcriptase. Their anti-HIV-1 activity was studied in CEM-cell culture and against HIV-1 reverse transcriptase. It was found that several compounds exhibited marked activity.
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Paramonova M. P. et al. Synthesis and Anti-HIV-1 activity of 1-[ω-(Phenoxy)Alkyl and -Alkenyl]Uracil derivatives // Pharmaceutical Chemistry Journal. 2013. Vol. 47. No. 9. pp. 459-463.
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Paramonova M. P., Babkov D. A., Valuev Elliston V. T., A.V. I., Kochetkov S. N., Pannecouque C., Ozerov A., Balzarini J., Novikov M. Synthesis and Anti-HIV-1 activity of 1-[ω-(Phenoxy)Alkyl and -Alkenyl]Uracil derivatives // Pharmaceutical Chemistry Journal. 2013. Vol. 47. No. 9. pp. 459-463.
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TY - JOUR
DO - 10.1007/s11094-013-0980-8
UR - https://doi.org/10.1007/s11094-013-0980-8
TI - Synthesis and Anti-HIV-1 activity of 1-[ω-(Phenoxy)Alkyl and -Alkenyl]Uracil derivatives
T2 - Pharmaceutical Chemistry Journal
AU - Paramonova, M P
AU - Babkov, D A
AU - Valuev Elliston, V T
AU - A.V., Ivanov
AU - Kochetkov, S. N.
AU - Pannecouque, C
AU - Ozerov, A.A.
AU - Balzarini, J.
AU - Novikov, M.S.
PY - 2013
DA - 2013/12/11
PB - Springer Nature
SP - 459-463
IS - 9
VL - 47
SN - 0091-150X
SN - 1573-9031
ER -
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@article{2013_Paramonova,
author = {M P Paramonova and D A Babkov and V T Valuev Elliston and Ivanov A.V. and S. N. Kochetkov and C Pannecouque and A.A. Ozerov and J. Balzarini and M.S. Novikov},
title = {Synthesis and Anti-HIV-1 activity of 1-[ω-(Phenoxy)Alkyl and -Alkenyl]Uracil derivatives},
journal = {Pharmaceutical Chemistry Journal},
year = {2013},
volume = {47},
publisher = {Springer Nature},
month = {dec},
url = {https://doi.org/10.1007/s11094-013-0980-8},
number = {9},
pages = {459--463},
doi = {10.1007/s11094-013-0980-8}
}
MLA
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Paramonova, M. P., et al. “Synthesis and Anti-HIV-1 activity of 1-[ω-(Phenoxy)Alkyl and -Alkenyl]Uracil derivatives.” Pharmaceutical Chemistry Journal, vol. 47, no. 9, Dec. 2013, pp. 459-463. https://doi.org/10.1007/s11094-013-0980-8.