Synthesis and Antibacterial Activity of Hybrid Supramolecular Complexes Based on Tetracycline/Doxycycline and Water-Soluble C60-Fullerene Derivatives
Тип публикации: Journal Article
Дата публикации: 2017-01-06
scimago Q4
wos Q4
БС3
SJR: 0.219
CiteScore: 1.4
Impact factor: 1.0
ISSN: 0091150X, 15739031
Drug Discovery
Pharmacology
Краткое описание
Water-soluble pentasubstituted anionic and cationic C60-fullerene derivatives were synthesized in highly selective reactions of chlorofullerene C60Cl6 with captopril and an aliphatic amine. Hybrid supramolecular complexes of the functionalized C60-fullerene derivatives and tetracycline antibiotics (in a stoichiometric 1:1 mole ratio) with polymodal hydrodynamic-radius distributions were synthesized in aqueous solution as nano-sized micelles and vesicles. Hybrid complexes of the antibiotics and cationic amino-C60-fullerene derivatives exhibited synergic antibacterial effects that were more pronounced against a tetracycline-resistant Escherichia coli strain (carrier of the Tc R gene).
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Zhilenkov A. V. et al. Synthesis and Antibacterial Activity of Hybrid Supramolecular Complexes Based on Tetracycline/Doxycycline and Water-Soluble C60-Fullerene Derivatives // Pharmaceutical Chemistry Journal. 2017. Vol. 50. No. 10. pp. 637-641.
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Zhilenkov A. V., Khakina E. A., Troshin P. A., Inchagova K. S., Deryabin D. G. Synthesis and Antibacterial Activity of Hybrid Supramolecular Complexes Based on Tetracycline/Doxycycline and Water-Soluble C60-Fullerene Derivatives // Pharmaceutical Chemistry Journal. 2017. Vol. 50. No. 10. pp. 637-641.
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TY - JOUR
DO - 10.1007/s11094-017-1505-7
UR - https://doi.org/10.1007/s11094-017-1505-7
TI - Synthesis and Antibacterial Activity of Hybrid Supramolecular Complexes Based on Tetracycline/Doxycycline and Water-Soluble C60-Fullerene Derivatives
T2 - Pharmaceutical Chemistry Journal
AU - Zhilenkov, A. V.
AU - Khakina, E A
AU - Troshin, P A
AU - Inchagova, K S
AU - Deryabin, D. G.
PY - 2017
DA - 2017/01/06
PB - Springer Nature
SP - 637-641
IS - 10
VL - 50
SN - 0091-150X
SN - 1573-9031
ER -
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@article{2017_Zhilenkov,
author = {A. V. Zhilenkov and E A Khakina and P A Troshin and K S Inchagova and D. G. Deryabin},
title = {Synthesis and Antibacterial Activity of Hybrid Supramolecular Complexes Based on Tetracycline/Doxycycline and Water-Soluble C60-Fullerene Derivatives},
journal = {Pharmaceutical Chemistry Journal},
year = {2017},
volume = {50},
publisher = {Springer Nature},
month = {jan},
url = {https://doi.org/10.1007/s11094-017-1505-7},
number = {10},
pages = {637--641},
doi = {10.1007/s11094-017-1505-7}
}
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MLA
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Zhilenkov, A. V., et al. “Synthesis and Antibacterial Activity of Hybrid Supramolecular Complexes Based on Tetracycline/Doxycycline and Water-Soluble C60-Fullerene Derivatives.” Pharmaceutical Chemistry Journal, vol. 50, no. 10, Jan. 2017, pp. 637-641. https://doi.org/10.1007/s11094-017-1505-7.
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