Hepatoprotective and Choleretic Properties of Levopimaric Acid Derivatives
Publication type: Journal Article
Publication date: 2017-08-01
scimago Q4
wos Q4
SJR: 0.219
CiteScore: 1.4
Impact factor: 1.0
ISSN: 0091150X, 15739031
Drug Discovery
Pharmacology
Abstract
The hepatoprotective and choleretic activities of three levopimaric acid derivatives were studied experimentally using a CCl4-induced acute hepatitis model in rats. It was established that all investigated levopimaric acid derivatives tended to increase bile secretion whereas (5R,9R,13S,18S)-20-isopropyl-5,9-dimethyl-17-{[(4-methylphenyl)sulfonyl]imino}-14-oxopentacyclo[10.6.2.01, 10.04, 9.013, 18]eicosa-15,19-diene-5-carboxylic acid (I) and dimethyl (4bS,8R)-2-isopropyl-3′-4b,8-trimethyl-2′,4′-dioxo-4,4a,4b,5,6,7,8,8a,9,10-decahydro-3H-spiro[3,10a-ethanophenanthrene-11,5′-[1,3]thiazolidine]-8,12-dicarboxylate (II) reduced transaminase enzyme levels in blood serum.
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Vafina G. F. et al. Hepatoprotective and Choleretic Properties of Levopimaric Acid Derivatives // Pharmaceutical Chemistry Journal. 2017. Vol. 51. No. 5. pp. 348-350.
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Vafina G. F., Uzbekov A. R., Sapozhnikova T. A., Khisamutdinova R. Yu., Gabdrakhmanova S. F., Makara N. S., Zarudii F. S. Hepatoprotective and Choleretic Properties of Levopimaric Acid Derivatives // Pharmaceutical Chemistry Journal. 2017. Vol. 51. No. 5. pp. 348-350.
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RIS
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TY - JOUR
DO - 10.1007/s11094-017-1612-5
UR - https://doi.org/10.1007/s11094-017-1612-5
TI - Hepatoprotective and Choleretic Properties of Levopimaric Acid Derivatives
T2 - Pharmaceutical Chemistry Journal
AU - Vafina, G F
AU - Uzbekov, A R
AU - Sapozhnikova, T A
AU - Khisamutdinova, R Yu
AU - Gabdrakhmanova, S F
AU - Makara, N S
AU - Zarudii, F S
PY - 2017
DA - 2017/08/01
PB - Springer Nature
SP - 348-350
IS - 5
VL - 51
SN - 0091-150X
SN - 1573-9031
ER -
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BibTex (up to 50 authors)
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@article{2017_Vafina,
author = {G F Vafina and A R Uzbekov and T A Sapozhnikova and R Yu Khisamutdinova and S F Gabdrakhmanova and N S Makara and F S Zarudii},
title = {Hepatoprotective and Choleretic Properties of Levopimaric Acid Derivatives},
journal = {Pharmaceutical Chemistry Journal},
year = {2017},
volume = {51},
publisher = {Springer Nature},
month = {aug},
url = {https://doi.org/10.1007/s11094-017-1612-5},
number = {5},
pages = {348--350},
doi = {10.1007/s11094-017-1612-5}
}
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MLA
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Vafina, G. F., et al. “Hepatoprotective and Choleretic Properties of Levopimaric Acid Derivatives.” Pharmaceutical Chemistry Journal, vol. 51, no. 5, Aug. 2017, pp. 348-350. https://doi.org/10.1007/s11094-017-1612-5.