Mixed Salts of Cobalt (II) with Ketoand Mercaptocarboxylic Acids – A Novel Potential Type of Antidote for Cyanides
V Yu Kovtun
1
,
Yu. A. Davidovich
1
,
V D Gladkikh
1
,
S.V. Kozlov
1
,
I E Chikunov
1
,
M V Melikhova
2
,
S V Kolbasov
2
,
S P Nechiporenko
2
1
Farmazashchita Scientific-Industrial Center, Federal Medical-Biological Agency, Khimki, Russia
|
Publication type: Journal Article
Publication date: 2021-02-02
scimago Q4
wos Q4
SJR: 0.219
CiteScore: 1.4
Impact factor: 1.0
ISSN: 0091150X, 15739031
Drug Discovery
Pharmacology
Abstract
We report here the synthesis of mixed salts of cobalt (II) with α-ketocarboxylic and mercaptocarboxylic acids, which have different types of antidote activity, in a single molecule. Simultaneous administration of the mixed cobalt salt with poison (sodium cyanide) at doses corresponding to the LD50 and LD99 ameliorated the main symptoms of poisoning by 75 – 100% and prevented death. The index of protection (IP) and antidote power (AP) on intragastric administration of compound 1a at a dose of 300 mg/kg immediately after sodium cyanide poisoning were 1.40 and 1.08 respectively. Prophylactic administration 30 min before poison increased these values 1.8-fold, giving IP = 2.5 and AP = 1.9.
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Kovtun V. Yu. et al. Mixed Salts of Cobalt (II) with Ketoand Mercaptocarboxylic Acids – A Novel Potential Type of Antidote for Cyanides // Pharmaceutical Chemistry Journal. 2021. Vol. 54. No. 11. pp. 1136-1139.
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Kovtun V. Yu., Davidovich Y. A., Gladkikh V. D., Kozlov S., Chikunov I. E., Melikhova M. V., Kolbasov S. V., Nechiporenko S. P. Mixed Salts of Cobalt (II) with Ketoand Mercaptocarboxylic Acids – A Novel Potential Type of Antidote for Cyanides // Pharmaceutical Chemistry Journal. 2021. Vol. 54. No. 11. pp. 1136-1139.
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TY - JOUR
DO - 10.1007/s11094-021-02331-1
UR - https://doi.org/10.1007/s11094-021-02331-1
TI - Mixed Salts of Cobalt (II) with Ketoand Mercaptocarboxylic Acids – A Novel Potential Type of Antidote for Cyanides
T2 - Pharmaceutical Chemistry Journal
AU - Kovtun, V Yu
AU - Davidovich, Yu. A.
AU - Gladkikh, V D
AU - Kozlov, S.V.
AU - Chikunov, I E
AU - Melikhova, M V
AU - Kolbasov, S V
AU - Nechiporenko, S P
PY - 2021
DA - 2021/02/02
PB - Springer Nature
SP - 1136-1139
IS - 11
VL - 54
SN - 0091-150X
SN - 1573-9031
ER -
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@article{2021_Kovtun,
author = {V Yu Kovtun and Yu. A. Davidovich and V D Gladkikh and S.V. Kozlov and I E Chikunov and M V Melikhova and S V Kolbasov and S P Nechiporenko},
title = {Mixed Salts of Cobalt (II) with Ketoand Mercaptocarboxylic Acids – A Novel Potential Type of Antidote for Cyanides},
journal = {Pharmaceutical Chemistry Journal},
year = {2021},
volume = {54},
publisher = {Springer Nature},
month = {feb},
url = {https://doi.org/10.1007/s11094-021-02331-1},
number = {11},
pages = {1136--1139},
doi = {10.1007/s11094-021-02331-1}
}
Cite this
MLA
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Kovtun, V. Yu., et al. “Mixed Salts of Cobalt (II) with Ketoand Mercaptocarboxylic Acids – A Novel Potential Type of Antidote for Cyanides.” Pharmaceutical Chemistry Journal, vol. 54, no. 11, Feb. 2021, pp. 1136-1139. https://doi.org/10.1007/s11094-021-02331-1.
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