Diaminocarbene Complexes of Palladium(II) Containing 2-Aminooxazole and 2-Aminothiazole Heterocyclic Ligands as Potential Antitumor Agents
Publication type: Journal Article
Publication date: 2021-05-04
scimago Q4
wos Q4
SJR: 0.219
CiteScore: 1.4
Impact factor: 1.0
ISSN: 0091150X, 15739031
Drug Discovery
Pharmacology
Abstract
A new diaminocarbene cis-palladium(II) complex containing a 2-aminobenzoxazole ligand was synthesized by reacting cis-[PdCl2(CNCy)2] and 2-aminobenzoxazole. The structure and composition of the obtained complex were proven by NMR spectroscopy and high-resolution mass spectrometry. The cytotoxicities of the obtained complex and structurally similar palladium(II) complexes containing a 2-aminothiazole ligand were tested against human cancer cells of various histogenesis (MCF-7, HL60, HeLa, DLD1, A431). The activities of several complexes against cancer cells were higher than those of the reference drug cisplatin and the free ligands, i.e., 2-aminooxazole and substituted 2-aminothiazoles.
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Boyarskii V. P. et al. Diaminocarbene Complexes of Palladium(II) Containing 2-Aminooxazole and 2-Aminothiazole Heterocyclic Ligands as Potential Antitumor Agents // Pharmaceutical Chemistry Journal. 2021. Vol. 55. No. 2. pp. 130-132.
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Boyarskii V. P., Mikherdov A. S., Baikov S. V., Savko P. Yu., Suezov R. V., Trifonov R. E. Diaminocarbene Complexes of Palladium(II) Containing 2-Aminooxazole and 2-Aminothiazole Heterocyclic Ligands as Potential Antitumor Agents // Pharmaceutical Chemistry Journal. 2021. Vol. 55. No. 2. pp. 130-132.
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TY - JOUR
DO - 10.1007/s11094-021-02393-1
UR - https://link.springer.com/10.1007/s11094-021-02393-1
TI - Diaminocarbene Complexes of Palladium(II) Containing 2-Aminooxazole and 2-Aminothiazole Heterocyclic Ligands as Potential Antitumor Agents
T2 - Pharmaceutical Chemistry Journal
AU - Boyarskii, V P
AU - Mikherdov, A S
AU - Baikov, S V
AU - Savko, P Yu
AU - Suezov, R V
AU - Trifonov, R E
PY - 2021
DA - 2021/05/04
PB - Springer Nature
SP - 130-132
IS - 2
VL - 55
SN - 0091-150X
SN - 1573-9031
ER -
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@article{2021_Boyarskii,
author = {V P Boyarskii and A S Mikherdov and S V Baikov and P Yu Savko and R V Suezov and R E Trifonov},
title = {Diaminocarbene Complexes of Palladium(II) Containing 2-Aminooxazole and 2-Aminothiazole Heterocyclic Ligands as Potential Antitumor Agents},
journal = {Pharmaceutical Chemistry Journal},
year = {2021},
volume = {55},
publisher = {Springer Nature},
month = {may},
url = {https://link.springer.com/10.1007/s11094-021-02393-1},
number = {2},
pages = {130--132},
doi = {10.1007/s11094-021-02393-1}
}
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Boyarskii, V. P., et al. “Diaminocarbene Complexes of Palladium(II) Containing 2-Aminooxazole and 2-Aminothiazole Heterocyclic Ligands as Potential Antitumor Agents.” Pharmaceutical Chemistry Journal, vol. 55, no. 2, May. 2021, pp. 130-132. https://link.springer.com/10.1007/s11094-021-02393-1.
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