Pharmaceutical Chemistry Journal

, том 55 , издание 2 , страницы 130-132

Diaminocarbene Complexes of Palladium(II) Containing 2-Aminooxazole and 2-Aminothiazole Heterocyclic Ligands as Potential Antitumor Agents

Тип публикации: Journal Article

Дата публикации: 2021-05-04

Springer Nature

Pharmaceutical Chemistry Journal

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SJR: 0.219

CiteScore: 1.4

Impact factor: 1

ISSN: 0091150X, 15739031

DOI: 10.1007/s11094-021-02393-1

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Drug Discovery

Pharmacology

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A new diaminocarbene cis-palladium(II) complex containing a 2-aminobenzoxazole ligand was synthesized by reacting cis-[PdCl2(CNCy)2] and 2-aminobenzoxazole. The structure and composition of the obtained complex were proven by NMR spectroscopy and high-resolution mass spectrometry. The cytotoxicities of the obtained complex and structurally similar palladium(II) complexes containing a 2-aminothiazole ligand were tested against human cancer cells of various histogenesis (MCF-7, HL60, HeLa, DLD1, A431). The activities of several complexes against cancer cells were higher than those of the reference drug cisplatin and the free ligands, i.e., 2-aminooxazole and substituted 2-aminothiazoles.

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Inorganics	Inorganics, 1, 20% Inorganics 1 публикация, 20%
Russian Journal of General Chemistry	Russian Journal of General Chemistry, 1, 20% Russian Journal of General Chemistry 1 публикация, 20%
Russian Journal of Coordination Chemistry/Koordinatsionnaya Khimiya	Russian Journal of Coordination Chemistry/Koordinatsionnaya Khimiya, 1, 20% Russian Journal of Coordination Chemistry/Koordinatsionnaya Khimiya 1 публикация, 20%
Russian Chemical Bulletin	Russian Chemical Bulletin, 1, 20% Russian Chemical Bulletin 1 публикация, 20%
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Boyarskii V. P. et al. Diaminocarbene Complexes of Palladium(II) Containing 2-Aminooxazole and 2-Aminothiazole Heterocyclic Ligands as Potential Antitumor Agents // Pharmaceutical Chemistry Journal. 2021. Vol. 55. No. 2. pp. 130-132.

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Boyarskii V. P., Mikherdov A. S., Baikov S. V., Savko P. Yu., Suezov R. V., Trifonov R. E. Diaminocarbene Complexes of Palladium(II) Containing 2-Aminooxazole and 2-Aminothiazole Heterocyclic Ligands as Potential Antitumor Agents // Pharmaceutical Chemistry Journal. 2021. Vol. 55. No. 2. pp. 130-132.

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TY - JOUR

DO - 10.1007/s11094-021-02393-1

UR - https://link.springer.com/10.1007/s11094-021-02393-1

TI - Diaminocarbene Complexes of Palladium(II) Containing 2-Aminooxazole and 2-Aminothiazole Heterocyclic Ligands as Potential Antitumor Agents

T2 - Pharmaceutical Chemistry Journal

AU - Boyarskii, V P

AU - Mikherdov, A S

AU - Baikov, S V

AU - Savko, P Yu

AU - Suezov, R V

AU - Trifonov, R E

PY - 2021

DA - 2021/05/04

PB - Springer Nature

SP - 130-132

IS - 2

VL - 55

SN - 0091-150X

SN - 1573-9031

ER -

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@article{2021_Boyarskii,

author = {V P Boyarskii and A S Mikherdov and S V Baikov and P Yu Savko and R V Suezov and R E Trifonov},

title = {Diaminocarbene Complexes of Palladium(II) Containing 2-Aminooxazole and 2-Aminothiazole Heterocyclic Ligands as Potential Antitumor Agents},

journal = {Pharmaceutical Chemistry Journal},

year = {2021},

volume = {55},

publisher = {Springer Nature},

month = {may},

url = {https://link.springer.com/10.1007/s11094-021-02393-1},

number = {2},

pages = {130--132},

doi = {10.1007/s11094-021-02393-1}

}

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Boyarskii, V. P., et al. “Diaminocarbene Complexes of Palladium(II) Containing 2-Aminooxazole and 2-Aminothiazole Heterocyclic Ligands as Potential Antitumor Agents.” Pharmaceutical Chemistry Journal, vol. 55, no. 2, May. 2021, pp. 130-132. https://link.springer.com/10.1007/s11094-021-02393-1.