Synthesis and Antibacterial Evaluation of (E)-5-Arylidene-6-Methyl-4,5-Dihydropyridazin-3(2)-Thione Derivatives
4
Department of Pharmaceutical Chemistry, Himalayan Institute of Pharmacy Research, Dehradun, India
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Publication type: Journal Article
Publication date: 2021-12-01
scimago Q4
wos Q4
SJR: 0.219
CiteScore: 1.4
Impact factor: 1.0
ISSN: 0091150X, 15739031
Drug Discovery
Pharmacology
Abstract
Some(E)-5-arylidene-6-methyl-4,5-dihydropyridazin-3(2H)-thione derivatives (5a-5f) were synthesized and evaluated as antimicrobial agents against Gram positive bacteria Staphylococcus aureus, Bacillus subtilis, and Gram negative bacteria Escherichia coli, and Pseudomonas aeruginosa strains. All the title compounds were characterized by their physical (TLC and M. P.), spectral (IR, 1H NMR) and mass spectroscopy (MS) data. Test results show that compounds 5b and 5e were found to be most effective antibacterial agents against both Gram positive and Gram negative bacterial strains. The presence of an electron attractor group on the aromatic ring as chloro group (5b) is favorable for that antibacterial activity. Derivatives (5c, 5d, 5f) containing the aromatic ring substituted by an electron donor groups (-OCH3, OH) inhibit the activity. All the newly synthesized compounds exhibit promising antimicrobial properties.
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Alghamdi S. et al. Synthesis and Antibacterial Evaluation of (E)-5-Arylidene-6-Methyl-4,5-Dihydropyridazin-3(2)-Thione Derivatives // Pharmaceutical Chemistry Journal. 2021. Vol. 55. No. 9. pp. 915-919.
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Alghamdi S., Imran M., Kamal M., Asif M. Synthesis and Antibacterial Evaluation of (E)-5-Arylidene-6-Methyl-4,5-Dihydropyridazin-3(2)-Thione Derivatives // Pharmaceutical Chemistry Journal. 2021. Vol. 55. No. 9. pp. 915-919.
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TY - JOUR
DO - 10.1007/s11094-021-02515-9
UR - https://doi.org/10.1007/s11094-021-02515-9
TI - Synthesis and Antibacterial Evaluation of (E)-5-Arylidene-6-Methyl-4,5-Dihydropyridazin-3(2)-Thione Derivatives
T2 - Pharmaceutical Chemistry Journal
AU - Alghamdi, Saad
AU - Imran, Mohd
AU - Kamal, Mehnaz
AU - Asif, Mohammad
PY - 2021
DA - 2021/12/01
PB - Springer Nature
SP - 915-919
IS - 9
VL - 55
SN - 0091-150X
SN - 1573-9031
ER -
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BibTex (up to 50 authors)
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@article{2021_Alghamdi,
author = {Saad Alghamdi and Mohd Imran and Mehnaz Kamal and Mohammad Asif},
title = {Synthesis and Antibacterial Evaluation of (E)-5-Arylidene-6-Methyl-4,5-Dihydropyridazin-3(2)-Thione Derivatives},
journal = {Pharmaceutical Chemistry Journal},
year = {2021},
volume = {55},
publisher = {Springer Nature},
month = {dec},
url = {https://doi.org/10.1007/s11094-021-02515-9},
number = {9},
pages = {915--919},
doi = {10.1007/s11094-021-02515-9}
}
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MLA
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Alghamdi, Saad, et al. “Synthesis and Antibacterial Evaluation of (E)-5-Arylidene-6-Methyl-4,5-Dihydropyridazin-3(2)-Thione Derivatives.” Pharmaceutical Chemistry Journal, vol. 55, no. 9, Dec. 2021, pp. 915-919. https://doi.org/10.1007/s11094-021-02515-9.