Synthesis and anti-inflammatory activities of 4H-chromene and chromeno[2,3-b]pyridine derivatives
Тип публикации: Journal Article
Дата публикации: 2015-05-05
scimago Q2
wos Q2
БС2
SJR: 0.528
CiteScore: 5.7
Impact factor: 3.5
ISSN: 09226168, 15685675
General Chemistry
Краткое описание
Several derivatives of 4H-chromene and chromeno[2,3-b]pyridine were efficiently prepared under microwave irradiation in a one-pot reaction, and their anti-inflammatory activities were evaluated. Six synthetic products (1b, 1c, 1h, 2d, 2j, and 2l) exhibited more powerfully inhibited the production of tumor necrosis factor-α-induced nitric oxide (NO) than quercetin and exhibited comparable cell viability in both human and porcine chondrocytes. In particular, 2d at dosages of 10 and 20 mg/kg had a very potent anti-inflammatory effect by suppressing the formation of carrageenan-induced rat paw edema and prostaglandin E2. The results herein suggest that these compounds may have potential as structural templates in the design and development of new anti-inflammatory drugs.
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Chung S. et al. Synthesis and anti-inflammatory activities of 4H-chromene and chromeno[2,3-b]pyridine derivatives // Research on Chemical Intermediates. 2015. Vol. 42. No. 2. pp. 1195-1215.
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Chung S., Huang W., Huang C., Liu F., Huang R., Wu C., Lee A. Synthesis and anti-inflammatory activities of 4H-chromene and chromeno[2,3-b]pyridine derivatives // Research on Chemical Intermediates. 2015. Vol. 42. No. 2. pp. 1195-1215.
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TY - JOUR
DO - 10.1007/s11164-015-2081-7
UR - https://doi.org/10.1007/s11164-015-2081-7
TI - Synthesis and anti-inflammatory activities of 4H-chromene and chromeno[2,3-b]pyridine derivatives
T2 - Research on Chemical Intermediates
AU - Chung, Shu-Ting
AU - Huang, Wen-Hsin
AU - Huang, Chih-Kuo
AU - Liu, Feng-Cheng
AU - Huang, Ren-Yeong
AU - Wu, Chin-Chen
AU - Lee, An-Rong
PY - 2015
DA - 2015/05/05
PB - Springer Nature
SP - 1195-1215
IS - 2
VL - 42
SN - 0922-6168
SN - 1568-5675
ER -
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@article{2015_Chung,
author = {Shu-Ting Chung and Wen-Hsin Huang and Chih-Kuo Huang and Feng-Cheng Liu and Ren-Yeong Huang and Chin-Chen Wu and An-Rong Lee},
title = {Synthesis and anti-inflammatory activities of 4H-chromene and chromeno[2,3-b]pyridine derivatives},
journal = {Research on Chemical Intermediates},
year = {2015},
volume = {42},
publisher = {Springer Nature},
month = {may},
url = {https://doi.org/10.1007/s11164-015-2081-7},
number = {2},
pages = {1195--1215},
doi = {10.1007/s11164-015-2081-7}
}
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MLA
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Chung, Shu-Ting, et al. “Synthesis and anti-inflammatory activities of 4H-chromene and chromeno[2,3-b]pyridine derivatives.” Research on Chemical Intermediates, vol. 42, no. 2, May. 2015, pp. 1195-1215. https://doi.org/10.1007/s11164-015-2081-7.