Antitumor phosphate-containing lipids and non-phosphorus alkyl cationic glycerolipids: Chemical structures and perspectives of drug development
Publication type: Journal Article
Publication date: 2014-05-01
scimago Q3
SJR: 0.305
CiteScore: 2.8
Impact factor: —
ISSN: 10665285, 15739171
General Chemistry
Abstract
Candidates to antitumor drugs of lipid nature are reviewed. The biological effects of the following known antineoplastic phosphate-containing lipids are described: edelfosine, ilmofosine, milfosine, perifosine, and erufosine. Although the most active phosphate-containing lipid edelfosine causes the death of tumor cells of different tissue origin, it possesses a strong hemolytic effect and toxicity toward non-malignant counterparts. The phosphate-containing lipids can be inactivated by phospholipases, which gave rise to the search for the optimum structure of cationic glycerolipids containing no phosphate group and having a similar antitumor activity. The results of structural functional studies of the non-phosphorus cationic glycerolipids with the best antitumor activity are generalized.
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GOST
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Markova A. A. et al. Antitumor phosphate-containing lipids and non-phosphorus alkyl cationic glycerolipids: Chemical structures and perspectives of drug development // Russian Chemical Bulletin. 2014. Vol. 63. No. 5. pp. 1081-1087.
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Markova A. A., Plyavnik N. V., Morozova N. G., Maslov M. A., Shtil A. A. Antitumor phosphate-containing lipids and non-phosphorus alkyl cationic glycerolipids: Chemical structures and perspectives of drug development // Russian Chemical Bulletin. 2014. Vol. 63. No. 5. pp. 1081-1087.
Cite this
RIS
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TY - JOUR
DO - 10.1007/s11172-014-0552-4
UR - http://link.springer.com/10.1007/s11172-014-0552-4
TI - Antitumor phosphate-containing lipids and non-phosphorus alkyl cationic glycerolipids: Chemical structures and perspectives of drug development
T2 - Russian Chemical Bulletin
AU - Markova, A A
AU - Plyavnik, N V
AU - Morozova, N G
AU - Maslov, M A
AU - Shtil, A A
PY - 2014
DA - 2014/05/01
PB - Springer Nature
SP - 1081-1087
IS - 5
VL - 63
SN - 1066-5285
SN - 1573-9171
ER -
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BibTex (up to 50 authors)
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@article{2014_Markova,
author = {A A Markova and N V Plyavnik and N G Morozova and M A Maslov and A A Shtil},
title = {Antitumor phosphate-containing lipids and non-phosphorus alkyl cationic glycerolipids: Chemical structures and perspectives of drug development},
journal = {Russian Chemical Bulletin},
year = {2014},
volume = {63},
publisher = {Springer Nature},
month = {may},
url = {http://link.springer.com/10.1007/s11172-014-0552-4},
number = {5},
pages = {1081--1087},
doi = {10.1007/s11172-014-0552-4}
}
Cite this
MLA
Copy
Markova, A. A., et al. “Antitumor phosphate-containing lipids and non-phosphorus alkyl cationic glycerolipids: Chemical structures and perspectives of drug development.” Russian Chemical Bulletin, vol. 63, no. 5, May. 2014, pp. 1081-1087. http://link.springer.com/10.1007/s11172-014-0552-4.
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