Springer Nature
Russian Chemical Bulletin
,  volume 63 ,  issue 6 ,  pages 1350-1358

Synthesis of 5-(het)aryl- and 4,5-di(het)aryl-2-(thio)morpholinopyrimidines from 2-chloropyrimidine via SN H and cross-coupling reactions

Publication type: Journal Article
Publication date: 2014-06-01
Springer Nature
scimago Q3
SJR: 0.305
CiteScore: 2.8
Impact factor: —
ISSN: 10665285, 15739171
General Chemistry
Abstract
It has been shown that various combinations of nucleophilic aromatic substitution of hydrogen (SN H), SN ipso and the microwave-assisted Suzuki cross-coupling reactions are a versatile method for the synthesis of 5-(het)aryl-2-(thio)morpholinopyrimidine and 4,5-di(het)aryl-2-(thio)morpholinopyrimidine derivatives. All synthesized pyrimidines were found to be active in micromolar concentrations in vitro against Mycobacterium tuberculosis H37Rv.
Found 
Found 
1 citation
Gaynanova Gulnara
PhD in Chemistry
74 publications,  1 112 citations,  1 review
h-index: 18
A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences
A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences
Research interests
Colloidal chemistry
Drug delivery systems
Physical Chemistry
Supramolecular chemistry
Surfactants
1 citation
Dinastiya Ekaterina
29 publications,  586 citations,  33 reviews
h-index: 15
Postovsky Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences
Postovsky Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences
Saint Petersburg State University
Saint Petersburg State University
1 citation
Islamov Daut
PhD
168 publications,  1 577 citations
h-index: 20
Kazan Scientific Center of the Russian Academy of Sciences
Kazan Scientific Center of the Russian Academy of Sciences
Research interests
X-ray diffraction analysis
1 citation
Zakharova Lucia
DSc in Chemistry, professor
397 publications,  6 321 citations
h-index: 37
A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences
A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences
1 citation
Varaksin Mikhail
DSc in Chemistry
79 publications,  829 citations,  12 reviews
h-index: 18
Postovsky Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences
Postovsky Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences
Ural Federal University
Ural Federal University

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GOST |
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GOST Copy
Cheprakova E. M. et al. Synthesis of 5-(het)aryl- and 4,5-di(het)aryl-2-(thio)morpholinopyrimidines from 2-chloropyrimidine via SN H and cross-coupling reactions // Russian Chemical Bulletin. 2014. Vol. 63. No. 6. pp. 1350-1358.
GOST all authors (up to 50) Copy
Cheprakova E. M., Verbitskiy E. V., Ezhikova M. A., Kodess M., Pervova M. G., Slepukhin P. A., Toporova M. S., Kravchenko M. A., Medvinskiy I. D., Rusinov G., Charushin V. N. Synthesis of 5-(het)aryl- and 4,5-di(het)aryl-2-(thio)morpholinopyrimidines from 2-chloropyrimidine via SN H and cross-coupling reactions // Russian Chemical Bulletin. 2014. Vol. 63. No. 6. pp. 1350-1358.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1007/s11172-014-0602-y
UR - https://doi.org/10.1007/s11172-014-0602-y
TI - Synthesis of 5-(het)aryl- and 4,5-di(het)aryl-2-(thio)morpholinopyrimidines from 2-chloropyrimidine via SN H and cross-coupling reactions
T2 - Russian Chemical Bulletin
AU - Cheprakova, E M
AU - Verbitskiy, E V
AU - Ezhikova, M A
AU - Kodess, M.I
AU - Pervova, M G
AU - Slepukhin, P A
AU - Toporova, M S
AU - Kravchenko, M A
AU - Medvinskiy, I D
AU - Rusinov, G.L.
AU - Charushin, V. N.
PY - 2014
DA - 2014/06/01
PB - Springer Nature
SP - 1350-1358
IS - 6
VL - 63
SN - 1066-5285
SN - 1573-9171
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2014_Cheprakova,
author = {E M Cheprakova and E V Verbitskiy and M A Ezhikova and M.I Kodess and M G Pervova and P A Slepukhin and M S Toporova and M A Kravchenko and I D Medvinskiy and G.L. Rusinov and V. N. Charushin},
title = {Synthesis of 5-(het)aryl- and 4,5-di(het)aryl-2-(thio)morpholinopyrimidines from 2-chloropyrimidine via SN H and cross-coupling reactions},
journal = {Russian Chemical Bulletin},
year = {2014},
volume = {63},
publisher = {Springer Nature},
month = {jun},
url = {https://doi.org/10.1007/s11172-014-0602-y},
number = {6},
pages = {1350--1358},
doi = {10.1007/s11172-014-0602-y}
}
MLA
Cite this
MLA Copy
Cheprakova, E. M., et al. “Synthesis of 5-(het)aryl- and 4,5-di(het)aryl-2-(thio)morpholinopyrimidines from 2-chloropyrimidine via SN H and cross-coupling reactions.” Russian Chemical Bulletin, vol. 63, no. 6, Jun. 2014, pp. 1350-1358. https://doi.org/10.1007/s11172-014-0602-y.