Synthesis and structure of potentially biologically active N-(silylmethyl)tetrahydropyrimidin-2-ones
Publication type: Journal Article
Publication date: 2014-09-01
scimago Q3
SJR: 0.305
CiteScore: 2.8
Impact factor: —
ISSN: 10665285, 15739171
General Chemistry
Abstract
A transsilylation of 1,3-bis(trimethylsilyl)tetrahydropyrimidin-2-one with (chloromethyl)-chlorosilanes ClCH2SiMenCl3–n (n = 0, 2) gave the corresponding 1,3-bis[(chlorosilyl)-methyl]tetrahydropyrimidin-2-ones. New Si-containing tetrahydropyrimidin-2-ones were synthesized by the exchange reactions at the Si—Cl and Si—N bonds of these compounds. The structures of all the synthesized compounds were confirmed by multinuclear NMR spectroscopy. Virtual screening using the PASS program showed that these compounds can exhibit certain types of biological activity with 40—94% probability.
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Total citations:
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Lazareva N. F., Lazarev I. M. Synthesis and structure of potentially biologically active N-(silylmethyl)tetrahydropyrimidin-2-ones // Russian Chemical Bulletin. 2014. Vol. 63. No. 9. pp. 2081-2086.
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Lazareva N. F., Lazarev I. M. Synthesis and structure of potentially biologically active N-(silylmethyl)tetrahydropyrimidin-2-ones // Russian Chemical Bulletin. 2014. Vol. 63. No. 9. pp. 2081-2086.
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TY - JOUR
DO - 10.1007/s11172-014-0705-5
UR - https://doi.org/10.1007/s11172-014-0705-5
TI - Synthesis and structure of potentially biologically active N-(silylmethyl)tetrahydropyrimidin-2-ones
T2 - Russian Chemical Bulletin
AU - Lazareva, N F
AU - Lazarev, I M
PY - 2014
DA - 2014/09/01
PB - Springer Nature
SP - 2081-2086
IS - 9
VL - 63
SN - 1066-5285
SN - 1573-9171
ER -
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BibTex (up to 50 authors)
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@article{2014_Lazareva,
author = {N F Lazareva and I M Lazarev},
title = {Synthesis and structure of potentially biologically active N-(silylmethyl)tetrahydropyrimidin-2-ones},
journal = {Russian Chemical Bulletin},
year = {2014},
volume = {63},
publisher = {Springer Nature},
month = {sep},
url = {https://doi.org/10.1007/s11172-014-0705-5},
number = {9},
pages = {2081--2086},
doi = {10.1007/s11172-014-0705-5}
}
Cite this
MLA
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Lazareva, N. F., and I M Lazarev. “Synthesis and structure of potentially biologically active N-(silylmethyl)tetrahydropyrimidin-2-ones.” Russian Chemical Bulletin, vol. 63, no. 9, Sep. 2014, pp. 2081-2086. https://doi.org/10.1007/s11172-014-0705-5.