Dimephosphone analogs: A pharmacological aspect
V F Mironov
1
,
B I Buzykin
1
,
R S Garaev
2
,
D A Tatarinov
1
,
L R Kashapov
2
,
R V Chestnova
3
,
V. N. Nabiullin
1
,
A.V. Il'yasov
1
,
V V Zobova
1
3
cRepublican Clinical Tuberculosis Dispensary, Kazan, Russian Federation
|
Publication type: Journal Article
Publication date: 2014-09-01
scimago Q3
SJR: 0.305
CiteScore: 2.8
Impact factor: —
ISSN: 10665285, 15739171
General Chemistry
Abstract
We studied some pharmacological properties of dimephosphone P—C and aza analogs, viz., dimethyl (2-methyl-4-oxopent-2-yl)phosphonate, which is one of the first organophosphorus drugs having no anticholinesterase activity. Replacement of two P—O—C fragments in dialkyl (2-methyl-4-oxopent-2-yl)phosphonates with the P—C ones on going to dialkyl-(2-methyl-4-oxopent-2-yl)phosphine oxides results in a dramatic decrease in the acute toxicity of the latter to warmblooded animals. The toxicities of dimephosphone aza analogs and (γ-oxoalkyl)phosphine oxides under study depend on the nature of aza fragment introduced instead of the oxygen atom. Dimephosphone pyridinoylhydrazones were found to exhibit a high antiinflammatory activity, which increases the interest for this type compounds as promising tuberculostatics.
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Total citations:
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Citations from 2024:
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(7%)
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GOST
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Mironov V. F. et al. Dimephosphone analogs: A pharmacological aspect // Russian Chemical Bulletin. 2014. Vol. 63. No. 9. pp. 2114-2125.
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Mironov V. F., Buzykin B. I., Garaev R. S., Tatarinov D. A., Kashapov L. R., Chestnova R. V., Nabiullin V. N., Il'yasov A., Zobova V. V. Dimephosphone analogs: A pharmacological aspect // Russian Chemical Bulletin. 2014. Vol. 63. No. 9. pp. 2114-2125.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1007/s11172-014-0708-2
UR - https://doi.org/10.1007/s11172-014-0708-2
TI - Dimephosphone analogs: A pharmacological aspect
T2 - Russian Chemical Bulletin
AU - Mironov, V F
AU - Buzykin, B I
AU - Garaev, R S
AU - Tatarinov, D A
AU - Kashapov, L R
AU - Chestnova, R V
AU - Nabiullin, V. N.
AU - Il'yasov, A.V.
AU - Zobova, V V
PY - 2014
DA - 2014/09/01
PB - Springer Nature
SP - 2114-2125
IS - 9
VL - 63
SN - 1066-5285
SN - 1573-9171
ER -
Cite this
BibTex (up to 50 authors)
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@article{2014_Mironov,
author = {V F Mironov and B I Buzykin and R S Garaev and D A Tatarinov and L R Kashapov and R V Chestnova and V. N. Nabiullin and A.V. Il'yasov and V V Zobova},
title = {Dimephosphone analogs: A pharmacological aspect},
journal = {Russian Chemical Bulletin},
year = {2014},
volume = {63},
publisher = {Springer Nature},
month = {sep},
url = {https://doi.org/10.1007/s11172-014-0708-2},
number = {9},
pages = {2114--2125},
doi = {10.1007/s11172-014-0708-2}
}
Cite this
MLA
Copy
Mironov, V. F., et al. “Dimephosphone analogs: A pharmacological aspect.” Russian Chemical Bulletin, vol. 63, no. 9, Sep. 2014, pp. 2114-2125. https://doi.org/10.1007/s11172-014-0708-2.