Synthesis of new carbohydrate-containing cationic alkyl glycerolipids with antitumor activity
E V Shmendel
1
,
D K Shishova
1
,
T S Kubasova
1
,
L L Tyutyunnik
1
,
M A Maslov
1
,
N G Morozova
1
,
A A Shtil
2
Publication type: Journal Article
Publication date: 2015-07-01
scimago Q3
SJR: 0.305
CiteScore: 2.8
Impact factor: —
ISSN: 10665285, 15739171
General Chemistry
Abstract
New non-phosphorous carbohydrate-containing cationic alkyl glycerolipids bearing a ter- minal glycosyl moiety were synthesized. An approach used for the preparation of 2-O-ethyl-1-O-octadecyl-rac-glycerol allowed us to increase the yield of this key precursor by a factor of two. The carbohydrate-containing cationic alkyl glycerolipids induced tumor cell death and minimal damage to normal cells (in particular, erythrocytes), which makes the new compounds promising for practical purposes.
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Shmendel E. V. et al. Synthesis of new carbohydrate-containing cationic alkyl glycerolipids with antitumor activity // Russian Chemical Bulletin. 2015. Vol. 64. No. 7. pp. 1648-1654.
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Shmendel E. V., Perevoshchikova K. A., Shishova D. K., Kubasova T. S., Tyutyunnik L. L., Maslov M. A., Morozova N. G., Shtil A. A. Synthesis of new carbohydrate-containing cationic alkyl glycerolipids with antitumor activity // Russian Chemical Bulletin. 2015. Vol. 64. No. 7. pp. 1648-1654.
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TY - JOUR
DO - 10.1007/s11172-015-1055-7
UR - http://link.springer.com/10.1007/s11172-015-1055-7
TI - Synthesis of new carbohydrate-containing cationic alkyl glycerolipids with antitumor activity
T2 - Russian Chemical Bulletin
AU - Shmendel, E V
AU - Perevoshchikova, K A
AU - Shishova, D K
AU - Kubasova, T S
AU - Tyutyunnik, L L
AU - Maslov, M A
AU - Morozova, N G
AU - Shtil, A A
PY - 2015
DA - 2015/07/01
PB - Springer Nature
SP - 1648-1654
IS - 7
VL - 64
SN - 1066-5285
SN - 1573-9171
ER -
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@article{2015_Shmendel,
author = {E V Shmendel and K A Perevoshchikova and D K Shishova and T S Kubasova and L L Tyutyunnik and M A Maslov and N G Morozova and A A Shtil},
title = {Synthesis of new carbohydrate-containing cationic alkyl glycerolipids with antitumor activity},
journal = {Russian Chemical Bulletin},
year = {2015},
volume = {64},
publisher = {Springer Nature},
month = {jul},
url = {http://link.springer.com/10.1007/s11172-015-1055-7},
number = {7},
pages = {1648--1654},
doi = {10.1007/s11172-015-1055-7}
}
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MLA
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Shmendel, E. V., et al. “Synthesis of new carbohydrate-containing cationic alkyl glycerolipids with antitumor activity.” Russian Chemical Bulletin, vol. 64, no. 7, Jul. 2015, pp. 1648-1654. http://link.springer.com/10.1007/s11172-015-1055-7.
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