Immobilized phthalocyanines of magnesium, aluminum, and zinc in photodynamic treatment of mesenchymal stromal cells
Тип публикации: Journal Article
Дата публикации: 2016-01-01
scimago Q3
БС2
SJR: 0.305
CiteScore: 2.8
Impact factor: 1.7
ISSN: 10665285, 15739171
General Chemistry
Краткое описание
Phthalocyanines of magnesium, aluminum, and zinc immobilized on nano-sized silica and poly-N-vinylpyrrolidone in aqueous solutions were synthesized. Photochemical activity of the immobilized metal complexes was assessed by generation of singlet oxygen. Nontoxic concentrations of the new photosensitizers were determined in vitro. A comparative analysis of the efficiency of photodynamic therapy (PDT) was performed for immobilized phthalocyanines using mesenchymal stromal cells as a cell model. Aluminum phthalocyanine immobilized on nano-sized silica displayed the highest cell tropism. Irradiation of phthalocyanine-loaded cells resulted in generation of active singlet oxygen and subsequent apoptotic cell death. The use of immobilized phthalocyanines allowed decreasing the effective concentration (dose) of photosensitizer and enhancing the PDT cytotoxicity.
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Udartseva O. O. et al. Immobilized phthalocyanines of magnesium, aluminum, and zinc in photodynamic treatment of mesenchymal stromal cells // Russian Chemical Bulletin. 2016. Vol. 65. No. 1. pp. 277-281.
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Udartseva O. O., Lobanov A. V., Andreeva E. R., Buravkova L. B., Melnikov M. Ya. Immobilized phthalocyanines of magnesium, aluminum, and zinc in photodynamic treatment of mesenchymal stromal cells // Russian Chemical Bulletin. 2016. Vol. 65. No. 1. pp. 277-281.
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TY - JOUR
DO - 10.1007/s11172-016-1297-z
UR - https://doi.org/10.1007/s11172-016-1297-z
TI - Immobilized phthalocyanines of magnesium, aluminum, and zinc in photodynamic treatment of mesenchymal stromal cells
T2 - Russian Chemical Bulletin
AU - Udartseva, O O
AU - Lobanov, A. V.
AU - Andreeva, E R
AU - Buravkova, L B
AU - Melnikov, M Ya
PY - 2016
DA - 2016/01/01
PB - Springer Nature
SP - 277-281
IS - 1
VL - 65
SN - 1066-5285
SN - 1573-9171
ER -
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@article{2016_Udartseva,
author = {O O Udartseva and A. V. Lobanov and E R Andreeva and L B Buravkova and M Ya Melnikov},
title = {Immobilized phthalocyanines of magnesium, aluminum, and zinc in photodynamic treatment of mesenchymal stromal cells},
journal = {Russian Chemical Bulletin},
year = {2016},
volume = {65},
publisher = {Springer Nature},
month = {jan},
url = {https://doi.org/10.1007/s11172-016-1297-z},
number = {1},
pages = {277--281},
doi = {10.1007/s11172-016-1297-z}
}
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Udartseva, O. O., et al. “Immobilized phthalocyanines of magnesium, aluminum, and zinc in photodynamic treatment of mesenchymal stromal cells.” Russian Chemical Bulletin, vol. 65, no. 1, Jan. 2016, pp. 277-281. https://doi.org/10.1007/s11172-016-1297-z.