New quinoline- and isoquinoline-based multicomponent methods for the synthesis of 1,1(3,3)-dicyanotetrahydrobenzoindolizines
I A Sanin
1
,
A A Zubarev
1
,
A Yu Rudenko
1, 2
,
L A Rodinovskaya
1
,
E A Batuev
3
,
A. M. Shestopalov
1
Publication type: Journal Article
Publication date: 2018-02-01
scimago Q3
SJR: 0.305
CiteScore: 2.8
Impact factor: —
ISSN: 10665285, 15739171
General Chemistry
Abstract
Convenient multicomponent methods for the synthesis of benzannulated dihydroindolizines based on quinoline or isoquinoline, malononitrile, aromatic aldehydes and α-halomethylcarbonyl compounds were developed. Several alternative protocols of using the reactants were studied, starting with separate generation of two most probable intermediates and ending with the four-component condensation of all reactants. The scope of applicability of these methods was found, depending on the initial compounds used. The reaction is highly stereoselective with predominant formation of one of the possible isomers.
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Sanin I. A. et al. New quinoline- and isoquinoline-based multicomponent methods for the synthesis of 1,1(3,3)-dicyanotetrahydrobenzoindolizines // Russian Chemical Bulletin. 2018. Vol. 67. No. 2. pp. 297-303.
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Sanin I. A., Zubarev A. A., Rudenko A. Yu., Rodinovskaya L. A., Batuev E. A., Shestopalov A. M. New quinoline- and isoquinoline-based multicomponent methods for the synthesis of 1,1(3,3)-dicyanotetrahydrobenzoindolizines // Russian Chemical Bulletin. 2018. Vol. 67. No. 2. pp. 297-303.
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TY - JOUR
DO - 10.1007/s11172-018-2073-z
UR - http://link.springer.com/10.1007/s11172-018-2073-z
TI - New quinoline- and isoquinoline-based multicomponent methods for the synthesis of 1,1(3,3)-dicyanotetrahydrobenzoindolizines
T2 - Russian Chemical Bulletin
AU - Sanin, I A
AU - Zubarev, A A
AU - Rudenko, A Yu
AU - Rodinovskaya, L A
AU - Batuev, E A
AU - Shestopalov, A. M.
PY - 2018
DA - 2018/02/01
PB - Springer Nature
SP - 297-303
IS - 2
VL - 67
SN - 1066-5285
SN - 1573-9171
ER -
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@article{2018_Sanin,
author = {I A Sanin and A A Zubarev and A Yu Rudenko and L A Rodinovskaya and E A Batuev and A. M. Shestopalov},
title = {New quinoline- and isoquinoline-based multicomponent methods for the synthesis of 1,1(3,3)-dicyanotetrahydrobenzoindolizines},
journal = {Russian Chemical Bulletin},
year = {2018},
volume = {67},
publisher = {Springer Nature},
month = {feb},
url = {http://link.springer.com/10.1007/s11172-018-2073-z},
number = {2},
pages = {297--303},
doi = {10.1007/s11172-018-2073-z}
}
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MLA
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Sanin, I. A., et al. “New quinoline- and isoquinoline-based multicomponent methods for the synthesis of 1,1(3,3)-dicyanotetrahydrobenzoindolizines.” Russian Chemical Bulletin, vol. 67, no. 2, Feb. 2018, pp. 297-303. http://link.springer.com/10.1007/s11172-018-2073-z.
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