Russian Chemical Bulletin

, том 67 , издание 2 , страницы 297-303

New quinoline- and isoquinoline-based multicomponent methods for the synthesis of 1,1(3,3)-dicyanotetrahydrobenzoindolizines

I A Sanin ¹

A A Zubarev ¹

A Yu Rudenko ^{1, 2}

L A Rodinovskaya ¹

E A Batuev ³

A. M. Shestopalov ¹

Скрыть аффилиации авторов Показать аффилиации авторов: 3 аффилиации

N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences, Moscow, Russian Federation |

D. I. Mendeleev University of Chemical Technology of Russia, Moscow, Russian Federation |

V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russian Federation |

Тип публикации: Journal Article

Дата публикации: 2018-02-01

Springer Nature

Russian Chemical Bulletin

scimago Q3

БС2

SJR: 0.305

CiteScore: 2.8

Impact factor: —

ISSN: 10665285, 15739171

DOI: 10.1007/s11172-018-2073-z

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General Chemistry

Краткое описание

Convenient multicomponent methods for the synthesis of benzannulated dihydroindolizines based on quinoline or isoquinoline, malononitrile, aromatic aldehydes and α-halomethylcarbonyl compounds were developed. Several alternative protocols of using the reactants were studied, starting with separate generation of two most probable intermediates and ending with the four-component condensation of all reactants. The scope of applicability of these methods was found, depending on the initial compounds used. The reaction is highly stereoselective with predominant formation of one of the possible isomers.

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Sanin I. A. et al. New quinoline- and isoquinoline-based multicomponent methods for the synthesis of 1,1(3,3)-dicyanotetrahydrobenzoindolizines // Russian Chemical Bulletin. 2018. Vol. 67. No. 2. pp. 297-303.

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Sanin I. A., Zubarev A. A., Rudenko A. Yu., Rodinovskaya L. A., Batuev E. A., Shestopalov A. M. New quinoline- and isoquinoline-based multicomponent methods for the synthesis of 1,1(3,3)-dicyanotetrahydrobenzoindolizines // Russian Chemical Bulletin. 2018. Vol. 67. No. 2. pp. 297-303.

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TY - JOUR

DO - 10.1007/s11172-018-2073-z

UR - http://link.springer.com/10.1007/s11172-018-2073-z

TI - New quinoline- and isoquinoline-based multicomponent methods for the synthesis of 1,1(3,3)-dicyanotetrahydrobenzoindolizines

T2 - Russian Chemical Bulletin

AU - Sanin, I A

AU - Zubarev, A A

AU - Rudenko, A Yu

AU - Rodinovskaya, L A

AU - Batuev, E A

AU - Shestopalov, A. M.

PY - 2018

DA - 2018/02/01

PB - Springer Nature

SP - 297-303

IS - 2

VL - 67

SN - 1066-5285

SN - 1573-9171

ER -

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@article{2018_Sanin,

author = {I A Sanin and A A Zubarev and A Yu Rudenko and L A Rodinovskaya and E A Batuev and A. M. Shestopalov},

title = {New quinoline- and isoquinoline-based multicomponent methods for the synthesis of 1,1(3,3)-dicyanotetrahydrobenzoindolizines},

journal = {Russian Chemical Bulletin},

year = {2018},

volume = {67},

publisher = {Springer Nature},

month = {feb},

url = {http://link.springer.com/10.1007/s11172-018-2073-z},

number = {2},

pages = {297--303},

doi = {10.1007/s11172-018-2073-z}

}

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Sanin, I. A., et al. “New quinoline- and isoquinoline-based multicomponent methods for the synthesis of 1,1(3,3)-dicyanotetrahydrobenzoindolizines.” Russian Chemical Bulletin, vol. 67, no. 2, Feb. 2018, pp. 297-303. http://link.springer.com/10.1007/s11172-018-2073-z.