Synthesis, properties, and antianemic activity of new metal complexes of sodium pectinate with iron and calcium
S T Minzanova
1
,
V F Mironov
1
,
L. G. Mironova
1
,
A V Nemtarev
1
,
A B Vyshtakalyuk
1
,
K V Kholin
1
,
G R Nizameeva
2
,
V. A. Milyukov
1
Publication type: Journal Article
Publication date: 2019-01-01
scimago Q3
SJR: 0.305
CiteScore: 2.8
Impact factor: —
ISSN: 10665285, 15739171
General Chemistry
Abstract
A new water-soluble complex based on sodium pectinate with iron and calcium (P-NaFeCa) was synthesized. The regularities of the complexation of sodium pectinate (with a 35% content of COONa groups) with biogenic metals Ca and Fe were studied. The content of macro- and microelements was determined by atomic emission spectrometry; the product was identified by IR spectroscopy. Using atomic force microscopy, it was found that the average particle size of P-NaFeCa is ~170 nm. The efficiency of P-NaFeCa (per os) was studied for the first time in animals with hemolytic anemia modeled by administration of phenylhydrazine. It was experimentally shown that in vivo P-NaCaFe at a dose of 60 mg kg–1 containing 50% of the recommended therapeutic dose of iron helps to recover the number of erythrocytes and mean concentration hemoglobin in erythrocyte, which indicates the efficiency of P-NaCaFe as an agent restoring the blood parameters after exposure to hemolytic poisons.
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Minzanova S. T. et al. Synthesis, properties, and antianemic activity of new metal complexes of sodium pectinate with iron and calcium // Russian Chemical Bulletin. 2019. Vol. 68. No. 1. pp. 48-54.
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Minzanova S. T., Mironov V. F., Mironova L. G., Nemtarev A. V., Vyshtakalyuk A. B., Kholin K. V., Nizameeva G. R., Milyukov V. A. Synthesis, properties, and antianemic activity of new metal complexes of sodium pectinate with iron and calcium // Russian Chemical Bulletin. 2019. Vol. 68. No. 1. pp. 48-54.
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RIS
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TY - JOUR
DO - 10.1007/s11172-019-2414-6
UR - https://doi.org/10.1007/s11172-019-2414-6
TI - Synthesis, properties, and antianemic activity of new metal complexes of sodium pectinate with iron and calcium
T2 - Russian Chemical Bulletin
AU - Minzanova, S T
AU - Mironov, V F
AU - Mironova, L. G.
AU - Nemtarev, A V
AU - Vyshtakalyuk, A B
AU - Kholin, K V
AU - Nizameeva, G R
AU - Milyukov, V. A.
PY - 2019
DA - 2019/01/01
PB - Springer Nature
SP - 48-54
IS - 1
VL - 68
SN - 1066-5285
SN - 1573-9171
ER -
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BibTex (up to 50 authors)
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@article{2019_Minzanova,
author = {S T Minzanova and V F Mironov and L. G. Mironova and A V Nemtarev and A B Vyshtakalyuk and K V Kholin and G R Nizameeva and V. A. Milyukov},
title = {Synthesis, properties, and antianemic activity of new metal complexes of sodium pectinate with iron and calcium},
journal = {Russian Chemical Bulletin},
year = {2019},
volume = {68},
publisher = {Springer Nature},
month = {jan},
url = {https://doi.org/10.1007/s11172-019-2414-6},
number = {1},
pages = {48--54},
doi = {10.1007/s11172-019-2414-6}
}
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MLA
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Minzanova, S. T., et al. “Synthesis, properties, and antianemic activity of new metal complexes of sodium pectinate with iron and calcium.” Russian Chemical Bulletin, vol. 68, no. 1, Jan. 2019, pp. 48-54. https://doi.org/10.1007/s11172-019-2414-6.