Synthesis of (1S)-(+)-camphor-10-sulfonic acid derivatives and investigations in vitro and in silico of their antiviral activity as the inhibitors of fi lovirus infections
Тип публикации: Journal Article
Дата публикации: 2019-05-01
scimago Q3
БС2
SJR: 0.305
CiteScore: 2.8
Impact factor: —
ISSN: 10665285, 15739171
General Chemistry
Краткое описание
N-Heterocycle-containing (1S)-(+)-camphor-10-sulfonamide derivatives were synthesized. Their antiviral activity against the Ebola and Marburg viruses was estimated using a pseudovirus system based on the vesicular stomatitis virus. The derivatives bearing morpholine and triazole moieties demonstrated the highest inhibitory activity towards the Ebola virus glycoprotein. A moderate activity against the Marburg virus was found for a compound containing the piperidine moiety. A molecular modeling of the interaction between the synthesized derivatives and the binding site of glycoprotein of the Ebola virus was performed.
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Sokolova A. et al. Synthesis of (1S)-(+)-camphor-10-sulfonic acid derivatives and investigations in vitro and in silico of their antiviral activity as the inhibitors of fi lovirus infections // Russian Chemical Bulletin. 2019. Vol. 68. No. 5. pp. 1041-1046.
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Sokolova A., Baranova D. V., Yarovaya O. I., Baev D. S., Polezhaeva O. A., Zybkina A. V., Shcherbakov D. N., Tolstikova T. G., Salakhutdinov N. F. Synthesis of (1S)-(+)-camphor-10-sulfonic acid derivatives and investigations in vitro and in silico of their antiviral activity as the inhibitors of fi lovirus infections // Russian Chemical Bulletin. 2019. Vol. 68. No. 5. pp. 1041-1046.
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TY - JOUR
DO - 10.1007/s11172-019-2517-0
UR - https://doi.org/10.1007/s11172-019-2517-0
TI - Synthesis of (1S)-(+)-camphor-10-sulfonic acid derivatives and investigations in vitro and in silico of their antiviral activity as the inhibitors of fi lovirus infections
T2 - Russian Chemical Bulletin
AU - Sokolova, A.S.
AU - Baranova, D V
AU - Yarovaya, O. I.
AU - Baev, D. S.
AU - Polezhaeva, O A
AU - Zybkina, A V
AU - Shcherbakov, D. N.
AU - Tolstikova, T G
AU - Salakhutdinov, N. F.
PY - 2019
DA - 2019/05/01
PB - Springer Nature
SP - 1041-1046
IS - 5
VL - 68
SN - 1066-5285
SN - 1573-9171
ER -
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@article{2019_Sokolova,
author = {A.S. Sokolova and D V Baranova and O. I. Yarovaya and D. S. Baev and O A Polezhaeva and A V Zybkina and D. N. Shcherbakov and T G Tolstikova and N. F. Salakhutdinov},
title = {Synthesis of (1S)-(+)-camphor-10-sulfonic acid derivatives and investigations in vitro and in silico of their antiviral activity as the inhibitors of fi lovirus infections},
journal = {Russian Chemical Bulletin},
year = {2019},
volume = {68},
publisher = {Springer Nature},
month = {may},
url = {https://doi.org/10.1007/s11172-019-2517-0},
number = {5},
pages = {1041--1046},
doi = {10.1007/s11172-019-2517-0}
}
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MLA
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Sokolova, A.S., et al. “Synthesis of (1S)-(+)-camphor-10-sulfonic acid derivatives and investigations in vitro and in silico of their antiviral activity as the inhibitors of fi lovirus infections.” Russian Chemical Bulletin, vol. 68, no. 5, May. 2019, pp. 1041-1046. https://doi.org/10.1007/s11172-019-2517-0.