Gold-catalyzed cyclization in the synthesis of antimitotic 2,3-dihydrobenzo[b]oxepine derivatives of colchicine
S Yu Bukhvalova
1, 2
,
A A Maleev
2
,
Yu A Gracheva
2
,
Yu V Voitovich
2
,
S. K. Ignatov
2
,
E. V. Svirshchevskaya
3
,
Publication type: Journal Article
Publication date: 2019-12-01
scimago Q3
SJR: 0.305
CiteScore: 2.8
Impact factor: —
ISSN: 10665285, 15739171
General Chemistry
Abstract
New allocolchicine derivatives bearing 2,3-dihydrobenzo[b]oxepine moiety were synthesized via gold-catalyzed cyclization as a key synthetic step. The obtained 2,3-dihydrobenzo[b]oxepine-containing allocolchicinoids possess cytotoxic activity against HEK293, PANC-1, COL0357, HeLa, and Colon26 cancer cell lines at low micromolar range of concentrations.
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Total citations:
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Citations from 2024:
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(66.67%)
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Bukhvalova S. Yu. et al. Gold-catalyzed cyclization in the synthesis of antimitotic 2,3-dihydrobenzo[b]oxepine derivatives of colchicine // Russian Chemical Bulletin. 2019. Vol. 68. No. 12. pp. 2205-2215.
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Bukhvalova S. Yu., Maleev A. A., Gracheva Yu. A., Voitovich Yu. V., Ignatov S. K., Svirshchevskaya E. V., Fedorov A. Y. Gold-catalyzed cyclization in the synthesis of antimitotic 2,3-dihydrobenzo[b]oxepine derivatives of colchicine // Russian Chemical Bulletin. 2019. Vol. 68. No. 12. pp. 2205-2215.
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RIS
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TY - JOUR
DO - 10.1007/s11172-019-2689-7
UR - https://doi.org/10.1007/s11172-019-2689-7
TI - Gold-catalyzed cyclization in the synthesis of antimitotic 2,3-dihydrobenzo[b]oxepine derivatives of colchicine
T2 - Russian Chemical Bulletin
AU - Bukhvalova, S Yu
AU - Maleev, A A
AU - Gracheva, Yu A
AU - Voitovich, Yu V
AU - Ignatov, S. K.
AU - Svirshchevskaya, E. V.
AU - Fedorov, A. Yu.
PY - 2019
DA - 2019/12/01
PB - Springer Nature
SP - 2205-2215
IS - 12
VL - 68
SN - 1066-5285
SN - 1573-9171
ER -
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@article{2019_Bukhvalova,
author = {S Yu Bukhvalova and A A Maleev and Yu A Gracheva and Yu V Voitovich and S. K. Ignatov and E. V. Svirshchevskaya and A. Yu. Fedorov},
title = {Gold-catalyzed cyclization in the synthesis of antimitotic 2,3-dihydrobenzo[b]oxepine derivatives of colchicine},
journal = {Russian Chemical Bulletin},
year = {2019},
volume = {68},
publisher = {Springer Nature},
month = {dec},
url = {https://doi.org/10.1007/s11172-019-2689-7},
number = {12},
pages = {2205--2215},
doi = {10.1007/s11172-019-2689-7}
}
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MLA
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Bukhvalova, S. Yu., et al. “Gold-catalyzed cyclization in the synthesis of antimitotic 2,3-dihydrobenzo[b]oxepine derivatives of colchicine.” Russian Chemical Bulletin, vol. 68, no. 12, Dec. 2019, pp. 2205-2215. https://doi.org/10.1007/s11172-019-2689-7.
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