Methyl (S)-(5-methylidene-4-oxocyclopent-2-en-1-yl)acetate as a readily available pharmacologically important subunit of cross-conjugated cyclopentenone prostaglandins
Publication type: Journal Article
Publication date: 2020-03-01
scimago Q3
SJR: 0.305
CiteScore: 2.8
Impact factor: —
ISSN: 10665285, 15739171
General Chemistry
Abstract
A short and convenient synthesis of exomethylidenecyclopentenone core of cyclopentenone prostaglandins (+)−3 from (−) Corey lactone diol is described. The chiral 5-phenylthio and 5-phenylsulfonyl derivatives of exomethylidenecyclopentenone were obtained and their cytotoxic properties were studied in comparison with the synthesized earlier ethylthio and ethylsulfonyl derivatives of (±)−3, announced as its more stable bioisosteres.
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Vostrikov N. S. et al. Methyl (S)-(5-methylidene-4-oxocyclopent-2-en-1-yl)acetate as a readily available pharmacologically important subunit of cross-conjugated cyclopentenone prostaglandins // Russian Chemical Bulletin. 2020. Vol. 69. No. 3. pp. 547-551.
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Vostrikov N. S., Makaev Z. R., Zagitov V. V., Lakhvich F. A., Pashkovsky F. S., Miftakhov M. S. Methyl (S)-(5-methylidene-4-oxocyclopent-2-en-1-yl)acetate as a readily available pharmacologically important subunit of cross-conjugated cyclopentenone prostaglandins // Russian Chemical Bulletin. 2020. Vol. 69. No. 3. pp. 547-551.
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TY - JOUR
DO - 10.1007/s11172-020-2796-5
UR - https://doi.org/10.1007/s11172-020-2796-5
TI - Methyl (S)-(5-methylidene-4-oxocyclopent-2-en-1-yl)acetate as a readily available pharmacologically important subunit of cross-conjugated cyclopentenone prostaglandins
T2 - Russian Chemical Bulletin
AU - Vostrikov, N S
AU - Makaev, Z R
AU - Zagitov, V V
AU - Lakhvich, F A
AU - Pashkovsky, F S
AU - Miftakhov, M S
PY - 2020
DA - 2020/03/01
PB - Springer Nature
SP - 547-551
IS - 3
VL - 69
SN - 1066-5285
SN - 1573-9171
ER -
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@article{2020_Vostrikov,
author = {N S Vostrikov and Z R Makaev and V V Zagitov and F A Lakhvich and F S Pashkovsky and M S Miftakhov},
title = {Methyl (S)-(5-methylidene-4-oxocyclopent-2-en-1-yl)acetate as a readily available pharmacologically important subunit of cross-conjugated cyclopentenone prostaglandins},
journal = {Russian Chemical Bulletin},
year = {2020},
volume = {69},
publisher = {Springer Nature},
month = {mar},
url = {https://doi.org/10.1007/s11172-020-2796-5},
number = {3},
pages = {547--551},
doi = {10.1007/s11172-020-2796-5}
}
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MLA
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Vostrikov, N. S., et al. “Methyl (S)-(5-methylidene-4-oxocyclopent-2-en-1-yl)acetate as a readily available pharmacologically important subunit of cross-conjugated cyclopentenone prostaglandins.” Russian Chemical Bulletin, vol. 69, no. 3, Mar. 2020, pp. 547-551. https://doi.org/10.1007/s11172-020-2796-5.