Russian Chemical Bulletin

, том 69 , издание 4 , страницы 768-773

In silico consensus activity prediction, rational synthesis, and evaluation of antiglycation and antiplatelet activities of 3,6-disubstituted 1,2,4,5-tetrazines

R I Ishmetova ¹

D A Babkov ²

A F Kucheryavenko ²

V A Babkova ²

V S Sirotenko ²

N K Ignatenko ¹

S G Tolschina ¹

P M Vassiliev ²

G.L. Rusinov ^{1, 3}

A.A. Spasov ²

Скрыть аффилиации авторов Показать аффилиации авторов: 3 аффилиации

I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation |

Volgograd State Medical University, Ministry of Health of Russian Federation, Volgograd, Russian Federation |

Ural State Technical University named after the first President of Russia B. N. Yeltshin, Ekaterinburg, Russian Federation |

Тип публикации: Journal Article

Дата публикации: 2020-04-26

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Russian Chemical Bulletin

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SJR: 0.305

CiteScore: 2.8

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ISSN: 10665285, 15739171

DOI: 10.1007/s11172-020-2831-6

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General Chemistry

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According to the in silico consensus activity prediction, a series of 3,6-disubstituted 1,2,4,5-tetrazines were synthesized as promising inhibitors of the Maillard reaction. In addition to the studies of antiglycation activity, a comparative in vitro evaluation of the effect of the synthesized compounds on the ADP-induced rabbit platelet aggregation model was carried out. Compounds with antiglycation and antiplatelet activities significantly higher than that of the reference drugs, aminoguanidine and acetylsalicylic acid, were revealed.

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Ishmetova R. I. et al. In silico consensus activity prediction, rational synthesis, and evaluation of antiglycation and antiplatelet activities of 3,6-disubstituted 1,2,4,5-tetrazines // Russian Chemical Bulletin. 2020. Vol. 69. No. 4. pp. 768-773.

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Ishmetova R. I., Babkov D. A., Kucheryavenko A. F., Babkova V. A., Sirotenko V. S., Ignatenko N. K., Tolschina S. G., Vassiliev P. M., Rusinov G., Spasov A. In silico consensus activity prediction, rational synthesis, and evaluation of antiglycation and antiplatelet activities of 3,6-disubstituted 1,2,4,5-tetrazines // Russian Chemical Bulletin. 2020. Vol. 69. No. 4. pp. 768-773.

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TY - JOUR

DO - 10.1007/s11172-020-2831-6

UR - https://doi.org/10.1007/s11172-020-2831-6

TI - In silico consensus activity prediction, rational synthesis, and evaluation of antiglycation and antiplatelet activities of 3,6-disubstituted 1,2,4,5-tetrazines

T2 - Russian Chemical Bulletin

AU - Ishmetova, R I

AU - Babkov, D A

AU - Kucheryavenko, A F

AU - Babkova, V A

AU - Sirotenko, V S

AU - Ignatenko, N K

AU - Tolschina, S G

AU - Vassiliev, P M

AU - Rusinov, G.L.

AU - Spasov, A.A.

PY - 2020

DA - 2020/04/26

PB - Springer Nature

SP - 768-773

IS - 4

VL - 69

SN - 1066-5285

SN - 1573-9171

ER -

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@article{2020_Ishmetova,

author = {R I Ishmetova and D A Babkov and A F Kucheryavenko and V A Babkova and V S Sirotenko and N K Ignatenko and S G Tolschina and P M Vassiliev and G.L. Rusinov and A.A. Spasov},

title = {In silico consensus activity prediction, rational synthesis, and evaluation of antiglycation and antiplatelet activities of 3,6-disubstituted 1,2,4,5-tetrazines},

journal = {Russian Chemical Bulletin},

year = {2020},

volume = {69},

publisher = {Springer Nature},

month = {apr},

url = {https://doi.org/10.1007/s11172-020-2831-6},

number = {4},

pages = {768--773},

doi = {10.1007/s11172-020-2831-6}

}

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Ishmetova, R. I., et al. “In silico consensus activity prediction, rational synthesis, and evaluation of antiglycation and antiplatelet activities of 3,6-disubstituted 1,2,4,5-tetrazines.” Russian Chemical Bulletin, vol. 69, no. 4, Apr. 2020, pp. 768-773. https://doi.org/10.1007/s11172-020-2831-6.