In silico consensus activity prediction, rational synthesis, and evaluation of antiglycation and antiplatelet activities of 3,6-disubstituted 1,2,4,5-tetrazines
R I Ishmetova
1
,
D A Babkov
2
,
A F Kucheryavenko
2
,
V A Babkova
2
,
V S Sirotenko
2
,
N K Ignatenko
1
,
S G Tolschina
1
,
P M Vassiliev
2
,
G.L. Rusinov
1, 3
,
A.A. Spasov
2
Publication type: Journal Article
Publication date: 2020-04-26
scimago Q3
SJR: 0.305
CiteScore: 2.8
Impact factor: —
ISSN: 10665285, 15739171
General Chemistry
Abstract
According to the in silico consensus activity prediction, a series of 3,6-disubstituted 1,2,4,5-tetrazines were synthesized as promising inhibitors of the Maillard reaction. In addition to the studies of antiglycation activity, a comparative in vitro evaluation of the effect of the synthesized compounds on the ADP-induced rabbit platelet aggregation model was carried out. Compounds with antiglycation and antiplatelet activities significantly higher than that of the reference drugs, aminoguanidine and acetylsalicylic acid, were revealed.
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Ishmetova R. I. et al. In silico consensus activity prediction, rational synthesis, and evaluation of antiglycation and antiplatelet activities of 3,6-disubstituted 1,2,4,5-tetrazines // Russian Chemical Bulletin. 2020. Vol. 69. No. 4. pp. 768-773.
GOST all authors (up to 50)
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Ishmetova R. I., Babkov D. A., Kucheryavenko A. F., Babkova V. A., Sirotenko V. S., Ignatenko N. K., Tolschina S. G., Vassiliev P. M., Rusinov G., Spasov A. In silico consensus activity prediction, rational synthesis, and evaluation of antiglycation and antiplatelet activities of 3,6-disubstituted 1,2,4,5-tetrazines // Russian Chemical Bulletin. 2020. Vol. 69. No. 4. pp. 768-773.
Cite this
RIS
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TY - JOUR
DO - 10.1007/s11172-020-2831-6
UR - https://doi.org/10.1007/s11172-020-2831-6
TI - In silico consensus activity prediction, rational synthesis, and evaluation of antiglycation and antiplatelet activities of 3,6-disubstituted 1,2,4,5-tetrazines
T2 - Russian Chemical Bulletin
AU - Ishmetova, R I
AU - Babkov, D A
AU - Kucheryavenko, A F
AU - Babkova, V A
AU - Sirotenko, V S
AU - Ignatenko, N K
AU - Tolschina, S G
AU - Vassiliev, P M
AU - Rusinov, G.L.
AU - Spasov, A.A.
PY - 2020
DA - 2020/04/26
PB - Springer Nature
SP - 768-773
IS - 4
VL - 69
SN - 1066-5285
SN - 1573-9171
ER -
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BibTex (up to 50 authors)
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@article{2020_Ishmetova,
author = {R I Ishmetova and D A Babkov and A F Kucheryavenko and V A Babkova and V S Sirotenko and N K Ignatenko and S G Tolschina and P M Vassiliev and G.L. Rusinov and A.A. Spasov},
title = {In silico consensus activity prediction, rational synthesis, and evaluation of antiglycation and antiplatelet activities of 3,6-disubstituted 1,2,4,5-tetrazines},
journal = {Russian Chemical Bulletin},
year = {2020},
volume = {69},
publisher = {Springer Nature},
month = {apr},
url = {https://doi.org/10.1007/s11172-020-2831-6},
number = {4},
pages = {768--773},
doi = {10.1007/s11172-020-2831-6}
}
Cite this
MLA
Copy
Ishmetova, R. I., et al. “In silico consensus activity prediction, rational synthesis, and evaluation of antiglycation and antiplatelet activities of 3,6-disubstituted 1,2,4,5-tetrazines.” Russian Chemical Bulletin, vol. 69, no. 4, Apr. 2020, pp. 768-773. https://doi.org/10.1007/s11172-020-2831-6.
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