2-Amino- and 2-hydroxymethylbenzimidazolium bromides as protein tyrosine phosphatase 1В (PTP1В) inhibitors and other targets associated with diabetes mellitus
A.A. Spasov
1
,
O N Zhukovskaya
2
,
D A Babkov
1
,
A A Brigadirova
1
,
V A Babkova
1
,
A S Morkovnik
2
,
R.A. Litvinov
1
,
Publication type: Journal Article
Publication date: 2020-04-26
scimago Q3
SJR: 0.305
CiteScore: 2.8
Impact factor: —
ISSN: 10665285, 15739171
General Chemistry
Abstract
New 2-amino- and 2-hydroxymethylbenzimidazoles were synthesized and used to prepare the previously unknown 1,2,3-tri- and 1,2,3,5-tetrasubstituted benzimidazolium bromides with a biphenyl-containing substituent at the imidazole nitrogen atom. In some cases, these bromides exhibit activity against targets associated with diabetes mellitus. These compounds are strong protein tyrosine phosphatase 1B (PTP1B) inhibitors, exhibit chelating and antiglycation activity, but have no significant AT 1 receptor antagonist activity. Hence, biphenyl-containing benzimidazolium derivatives can be considered as a basis for the development of new promising agents for the treatment of type 2 diabetes mellitus (DM2) and other diseases mediated by high phosphatase PTP1B activity.
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Total citations:
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Citations from 2025:
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Spasov A. et al. 2-Amino- and 2-hydroxymethylbenzimidazolium bromides as protein tyrosine phosphatase 1В (PTP1В) inhibitors and other targets associated with diabetes mellitus // Russian Chemical Bulletin. 2020. Vol. 69. No. 4. pp. 774-780.
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Spasov A., Zhukovskaya O. N., Babkov D. A., Brigadirova A. A., Babkova V. A., Morkovnik A. S., Litvinov R., Sokolova E. V. 2-Amino- and 2-hydroxymethylbenzimidazolium bromides as protein tyrosine phosphatase 1В (PTP1В) inhibitors and other targets associated with diabetes mellitus // Russian Chemical Bulletin. 2020. Vol. 69. No. 4. pp. 774-780.
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TY - JOUR
DO - 10.1007/s11172-020-2832-5
UR - https://doi.org/10.1007/s11172-020-2832-5
TI - 2-Amino- and 2-hydroxymethylbenzimidazolium bromides as protein tyrosine phosphatase 1В (PTP1В) inhibitors and other targets associated with diabetes mellitus
T2 - Russian Chemical Bulletin
AU - Spasov, A.A.
AU - Zhukovskaya, O N
AU - Babkov, D A
AU - Brigadirova, A A
AU - Babkova, V A
AU - Morkovnik, A S
AU - Litvinov, R.A.
AU - Sokolova, E. V.
PY - 2020
DA - 2020/04/26
PB - Springer Nature
SP - 774-780
IS - 4
VL - 69
SN - 1066-5285
SN - 1573-9171
ER -
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BibTex (up to 50 authors)
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@article{2020_Spasov,
author = {A.A. Spasov and O N Zhukovskaya and D A Babkov and A A Brigadirova and V A Babkova and A S Morkovnik and R.A. Litvinov and E. V. Sokolova},
title = {2-Amino- and 2-hydroxymethylbenzimidazolium bromides as protein tyrosine phosphatase 1В (PTP1В) inhibitors and other targets associated with diabetes mellitus},
journal = {Russian Chemical Bulletin},
year = {2020},
volume = {69},
publisher = {Springer Nature},
month = {apr},
url = {https://doi.org/10.1007/s11172-020-2832-5},
number = {4},
pages = {774--780},
doi = {10.1007/s11172-020-2832-5}
}
Cite this
MLA
Copy
Spasov, A.A., et al. “2-Amino- and 2-hydroxymethylbenzimidazolium bromides as protein tyrosine phosphatase 1В (PTP1В) inhibitors and other targets associated with diabetes mellitus.” Russian Chemical Bulletin, vol. 69, no. 4, Apr. 2020, pp. 774-780. https://doi.org/10.1007/s11172-020-2832-5.