Synthesis of (1S)-(+)-camphor-10-sulfonamides and evaluation of their anti-filovirus activity
Тип публикации: Journal Article
Дата публикации: 2023-10-01
SCImago Q3
WOS Q3
БС2
SJR: 0.272
CiteScore: 2.8
Impact factor: 1.6
ISSN: 10665285, 15739171
General Chemistry
Краткое описание
A series of new (1S)-(+)-camphor-10-sulfonamides containing various substituents at the nitrogen atom were synthesized, and their antiviral properties against Ebola virus were evaluated using a vesicular stomatitis virus-based pseudovirus system. The reduction of the carbonyl group at the C(2) atom leads to a significant improvement in the antiviral efficacy, whereas the transformation into oxime results in the almost complete disappearance of antiviral activity. According to the evaluation of antiviral activity against natural Ebola virus, the lead compounds exhibit moderate inhibitory activity. Interactions of the lead compounds with the binding site of Ebola virus glycoprotein were studied by molecular modeling. A comparative analysis of the changes due to possible interactions of the synthesized ligands and known inhibitors with Ebola virus surface glycoprotein was carried out.
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Sokolova A. et al. Synthesis of (1S)-(+)-camphor-10-sulfonamides and evaluation of their anti-filovirus activity // Russian Chemical Bulletin. 2023. Vol. 72. No. 10. pp. 2536-2547.
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Sokolova A., Baranova D. V., Yarovaya O. I., Zybkina A. V., Mordvinova E. D., Zaykovskaya A. V., Baev D. S., Tolstikova T. G., Shcherbakov D. N., Pyankov O. V., Maksyutov R. A., Salakhutdinov N. F. Synthesis of (1S)-(+)-camphor-10-sulfonamides and evaluation of their anti-filovirus activity // Russian Chemical Bulletin. 2023. Vol. 72. No. 10. pp. 2536-2547.
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TY - JOUR
DO - 10.1007/s11172-023-4056-y
UR - https://doi.org/10.1007/s11172-023-4056-y
TI - Synthesis of (1S)-(+)-camphor-10-sulfonamides and evaluation of their anti-filovirus activity
T2 - Russian Chemical Bulletin
AU - Sokolova, A.S.
AU - Baranova, D V
AU - Yarovaya, O. I.
AU - Zybkina, A V
AU - Mordvinova, E. D.
AU - Zaykovskaya, A V
AU - Baev, D. S.
AU - Tolstikova, T G
AU - Shcherbakov, D. N.
AU - Pyankov, O V
AU - Maksyutov, R A
AU - Salakhutdinov, N. F.
PY - 2023
DA - 2023/10/01
PB - Springer Nature
SP - 2536-2547
IS - 10
VL - 72
SN - 1066-5285
SN - 1573-9171
ER -
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@article{2023_Sokolova,
author = {A.S. Sokolova and D V Baranova and O. I. Yarovaya and A V Zybkina and E. D. Mordvinova and A V Zaykovskaya and D. S. Baev and T G Tolstikova and D. N. Shcherbakov and O V Pyankov and R A Maksyutov and N. F. Salakhutdinov},
title = {Synthesis of (1S)-(+)-camphor-10-sulfonamides and evaluation of their anti-filovirus activity},
journal = {Russian Chemical Bulletin},
year = {2023},
volume = {72},
publisher = {Springer Nature},
month = {oct},
url = {https://doi.org/10.1007/s11172-023-4056-y},
number = {10},
pages = {2536--2547},
doi = {10.1007/s11172-023-4056-y}
}
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MLA
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Sokolova, A.S., et al. “Synthesis of (1S)-(+)-camphor-10-sulfonamides and evaluation of their anti-filovirus activity.” Russian Chemical Bulletin, vol. 72, no. 10, Oct. 2023, pp. 2536-2547. https://doi.org/10.1007/s11172-023-4056-y.
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