Springer Nature
Korean Journal of Chemical Engineering
,  volume 39 ,  issue 5 ,  pages 1097-1106

Energy metabolism in Chinese hamster ovary (CHO) cells: Productivity and beyond

Publication type: Journal Article
Publication date: 2022-02-22
Springer Nature
scimago Q2
wos Q2
SJR: 0.636
CiteScore: 5.2
Impact factor: 3.2
ISSN: 02561115, 19757220
General Chemistry
General Chemical Engineering
Abstract
Chinese hamster ovary (CHO) cell lines have been widely used to produce recombinant proteins. While the biosynthesis of recombinant proteins is energy-intensive, CHO cells exhibit inefficient metabolism, characterized by rapid conversion of glucose to lactate, possibly leading to lower cell growth and productivity of therapeutic proteins. Therefore, it is important to understand and engineer cellular metabolism to increase recombinant protein production. In this review, cellular energy metabolism of CHO cells with respect to protein synthesis is overviewed. Then, genetic and process engineering approaches to enhance metabolic efficiency are described, resulting in the improvement of cell culture performance. Finally, recent modeling technologies for understanding and predicting cellular metabolic behaviors are reviewed. These efforts will aid to further advance the biomanufacturing of therapeutic proteins.
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GOST |
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GOST Copy
Park J. U., Han H. J., Baik J. Y. Energy metabolism in Chinese hamster ovary (CHO) cells: Productivity and beyond // Korean Journal of Chemical Engineering. 2022. Vol. 39. No. 5. pp. 1097-1106.
GOST all authors (up to 50) Copy
Park J. U., Han H. J., Baik J. Y. Energy metabolism in Chinese hamster ovary (CHO) cells: Productivity and beyond // Korean Journal of Chemical Engineering. 2022. Vol. 39. No. 5. pp. 1097-1106.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1007/s11814-022-1062-y
UR - https://doi.org/10.1007/s11814-022-1062-y
TI - Energy metabolism in Chinese hamster ovary (CHO) cells: Productivity and beyond
T2 - Korean Journal of Chemical Engineering
AU - Park, Jong Uk
AU - Han, Hye Jin
AU - Baik, Jong Youn
PY - 2022
DA - 2022/02/22
PB - Springer Nature
SP - 1097-1106
IS - 5
VL - 39
SN - 0256-1115
SN - 1975-7220
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2022_Park,
author = {Jong Uk Park and Hye Jin Han and Jong Youn Baik},
title = {Energy metabolism in Chinese hamster ovary (CHO) cells: Productivity and beyond},
journal = {Korean Journal of Chemical Engineering},
year = {2022},
volume = {39},
publisher = {Springer Nature},
month = {feb},
url = {https://doi.org/10.1007/s11814-022-1062-y},
number = {5},
pages = {1097--1106},
doi = {10.1007/s11814-022-1062-y}
}
MLA
Cite this
MLA Copy
Park, Jong Uk, et al. “Energy metabolism in Chinese hamster ovary (CHO) cells: Productivity and beyond.” Korean Journal of Chemical Engineering, vol. 39, no. 5, Feb. 2022, pp. 1097-1106. https://doi.org/10.1007/s11814-022-1062-y.