Journal of Chemical Sciences, volume 133, issue 2, publication number 55
Synthesis, characterization and antioxidant activity studies of new coumarin tethered 1,3,4-oxadiazole analogues
1
Department of Chemistry, Yuvaraja College Mysore, Mysuru, India
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Publication type: Journal Article
Publication date: 2021-05-22
Journal:
Journal of Chemical Sciences
Quartile SCImago
Q3
Quartile WOS
Q3
Impact factor: 1.7
ISSN: 09743626, 09737103, 02534134
General Chemistry
Abstract
The present work describes the synthesis of a series of substituted 3-(5-phenyl-1,3,4-oxadiazol-2-yl)-2H-chromen-2-ones 7(a–j) using substituted aldehydes with analogues of hydrazine hydrates by grinding technique in the presence of Iodine which helps in the cyclization process. The structures of the synthesized compounds were elucidated by spectroscopic techniques such as IR, 1H NMR, 13C NMR, and LCMS. The comparative antioxidant property (using DPPH and hydroxyl radical scavenging) has been studied with the synthesized compounds 7(a-j) and the standards. Compounds 7d and 7i show the prominent radical scavenging activity. Synopsis: Series of ten new coumarin-oxadiazole hybrids synthesized in three steps starting from salicylaldehyde and diethylmalonate. All new compounds were spectroscopically characterized. The results of radical scavenging activities show that, two compounds of the series 7d and 7i displayed potent DPPH and hydroxyl radical activity comparable to the standards employed, and therefore acts as antioxidant leads.
Top-30
Citations by journals
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Russian Chemical Reviews
1 publication, 10%
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Green Chemistry Letters and Reviews
1 publication, 10%
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ChemistrySelect
1 publication, 10%
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Citations by publishers
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2
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Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 20%
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Springer Nature
2 publications, 20%
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Wiley
2 publications, 20%
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King Saud University
1 publication, 10%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 10%
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Taylor & Francis
1 publication, 10%
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- We do not take into account publications without a DOI.
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- Statistics recalculated weekly.
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Basappa V. C. et al. Synthesis, characterization and antioxidant activity studies of new coumarin tethered 1,3,4-oxadiazole analogues // Journal of Chemical Sciences. 2021. Vol. 133. No. 2. 55
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Basappa V. C., Penubolu S., Achutha D. K., Ajay Kumar K. Synthesis, characterization and antioxidant activity studies of new coumarin tethered 1,3,4-oxadiazole analogues // Journal of Chemical Sciences. 2021. Vol. 133. No. 2. 55
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TY - JOUR
DO - 10.1007/s12039-021-01914-5
UR - https://doi.org/10.1007/s12039-021-01914-5
TI - Synthesis, characterization and antioxidant activity studies of new coumarin tethered 1,3,4-oxadiazole analogues
T2 - Journal of Chemical Sciences
AU - Basappa, Vagish Channa
AU - Penubolu, Sudeep
AU - Achutha, Dileep Kumar
AU - Ajay Kumar, K.
PY - 2021
DA - 2021/05/22 00:00:00
PB - Springer Nature
IS - 2
VL - 133
SN - 0974-3626
SN - 0973-7103
SN - 0253-4134
ER -
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@article{2021_Basappa,
author = {Vagish Channa Basappa and Sudeep Penubolu and Dileep Kumar Achutha and K. Ajay Kumar},
title = {Synthesis, characterization and antioxidant activity studies of new coumarin tethered 1,3,4-oxadiazole analogues},
journal = {Journal of Chemical Sciences},
year = {2021},
volume = {133},
publisher = {Springer Nature},
month = {may},
url = {https://doi.org/10.1007/s12039-021-01914-5},
number = {2},
doi = {10.1007/s12039-021-01914-5}
}