Inhibitory effect of citral on NO production by suppression of iNOS expression and NF-κB activation in RAW264.7 cells
Hwa-Jeong Lee
1
,
Heon Sang Jeong
2
,
Dae Joong Kim
3
,
Young Hee Noh
4
,
Dong Yeon Yuk
1
,
Jin Tae Hong
1
Publication type: Journal Article
Publication date: 2008-03-01
scimago Q1
wos Q1
SJR: 1.870
CiteScore: 14.4
Impact factor: 7.5
ISSN: 02536269, 19763786
PubMed ID:
18409048
Organic Chemistry
Drug Discovery
Molecular Medicine
Abstract
Citral is a major compound of lemongrass (Cymbopogon citratus L.) that has many pharmacological activities such as anti-fungal and anti-bacterial effects. In this study, we investigated the anti-inflammatory effect of citral and defined its mechanism of action in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Citral (3–12 μg/mL) significantly inhibited LPS-induced nitric oxide (NO) production in a concentration-dependent manner (IC50: 6.5 μg/mL). Furthermore, it was found that citral effectively inhibited the transcriptional activity and expression of iNOS, and potently suppressed the DNA binding activity and nuclear translocation of NF-κB as well as IκB phosphorylation in a concentration dependent manner. These results suggest that citral is anti-inflammatory, and its effects may be due to the inhibition of NO production through the suppression of NF-κB activation.
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Lee H. et al. Inhibitory effect of citral on NO production by suppression of iNOS expression and NF-κB activation in RAW264.7 cells // Archives of Pharmacal Research. 2008. Vol. 31. No. 3. pp. 342-349.
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Lee H., Jeong H. S., Kim D. J., Noh Y. H., Yuk D. Y., Hong J. T. Inhibitory effect of citral on NO production by suppression of iNOS expression and NF-κB activation in RAW264.7 cells // Archives of Pharmacal Research. 2008. Vol. 31. No. 3. pp. 342-349.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1007/s12272-001-1162-0
UR - https://doi.org/10.1007/s12272-001-1162-0
TI - Inhibitory effect of citral on NO production by suppression of iNOS expression and NF-κB activation in RAW264.7 cells
T2 - Archives of Pharmacal Research
AU - Lee, Hwa-Jeong
AU - Jeong, Heon Sang
AU - Kim, Dae Joong
AU - Noh, Young Hee
AU - Yuk, Dong Yeon
AU - Hong, Jin Tae
PY - 2008
DA - 2008/03/01
PB - Pharmaceutical Society of Korea
SP - 342-349
IS - 3
VL - 31
PMID - 18409048
SN - 0253-6269
SN - 1976-3786
ER -
Cite this
BibTex (up to 50 authors)
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@article{2008_Lee,
author = {Hwa-Jeong Lee and Heon Sang Jeong and Dae Joong Kim and Young Hee Noh and Dong Yeon Yuk and Jin Tae Hong},
title = {Inhibitory effect of citral on NO production by suppression of iNOS expression and NF-κB activation in RAW264.7 cells},
journal = {Archives of Pharmacal Research},
year = {2008},
volume = {31},
publisher = {Pharmaceutical Society of Korea},
month = {mar},
url = {https://doi.org/10.1007/s12272-001-1162-0},
number = {3},
pages = {342--349},
doi = {10.1007/s12272-001-1162-0}
}
Cite this
MLA
Copy
Lee, Hwa-Jeong, et al. “Inhibitory effect of citral on NO production by suppression of iNOS expression and NF-κB activation in RAW264.7 cells.” Archives of Pharmacal Research, vol. 31, no. 3, Mar. 2008, pp. 342-349. https://doi.org/10.1007/s12272-001-1162-0.