Triterpenoid saponins from Clinopodium chinense (Benth.) O. Kuntze and their biological activity
Yin Di Zhu
1, 2
,
Jing-Yi Hong
2
,
Feng Da Bao
1
,
Na Xing
2, 3
,
Ling Tian Wang
4
,
Zhong Hao Sun
2
,
Yun Luo
2
,
Hai Jiang
2, 3
,
Xu-Dong Xu
2
,
Nai Liang Zhu
2
,
Hai-Feng Wu
2
,
Gui-Bo Sun
2
,
Jun-Shan Yang
2
Тип публикации: Journal Article
Дата публикации: 2017-09-11
scimago Q1
wos Q1
БС1
SJR: 1.870
CiteScore: 14.4
Impact factor: 7.5
ISSN: 02536269, 19763786
PubMed ID:
28895057
Organic Chemistry
Drug Discovery
Molecular Medicine
Краткое описание
Four new ursane-type triterpenoid saponins, clinopoursaponins A–D (1–4), six new oleanane-type triterpenoid saponins, clinopodiside VII–XII (5–10), as well as eight known triterpene analogues (11–18), were isolated from the aerial parts of Clinopodium chinense (Benth.) O. Kuntze. The structures of the new compounds were determined based on extensive spectral analyses, including 1D (1H and 13C) and 2D NMR experiments (COSY, NOESY, HSQC, 2D TOCSY, HSQC-TOCSY and HMBC), HR-ESI-MS and chemical methods. Compounds 1–18 were evaluated for their protective effects against anoxia/reoxygenation-induced apoptosis in H9c2 cells and cytotoxicities against murine mammary carcinoma cell line 4T1. Compounds 8, 9 and 18 exhibited significant protective effects, while compound 1 exhibited cytotoxic activity with IC50 value of 7.4 μm compared to 7.6 μm for the positive control 10-hydroxycamptothecin.
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ГОСТ
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Zhu Y. D. et al. Triterpenoid saponins from Clinopodium chinense (Benth.) O. Kuntze and their biological activity // Archives of Pharmacal Research. 2017. Vol. 41. No. 12. pp. 1117-1130.
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Zhu Y. D., Hong J., Bao F. D., Xing N., Wang L. T., Sun Z. H., Luo Y., Jiang H., Xu X., Zhu N. L., Wu H., Sun G., Yang J. Triterpenoid saponins from Clinopodium chinense (Benth.) O. Kuntze and their biological activity // Archives of Pharmacal Research. 2017. Vol. 41. No. 12. pp. 1117-1130.
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TY - JOUR
DO - 10.1007/s12272-017-0943-9
UR - https://doi.org/10.1007/s12272-017-0943-9
TI - Triterpenoid saponins from Clinopodium chinense (Benth.) O. Kuntze and their biological activity
T2 - Archives of Pharmacal Research
AU - Zhu, Yin Di
AU - Hong, Jing-Yi
AU - Bao, Feng Da
AU - Xing, Na
AU - Wang, Ling Tian
AU - Sun, Zhong Hao
AU - Luo, Yun
AU - Jiang, Hai
AU - Xu, Xu-Dong
AU - Zhu, Nai Liang
AU - Wu, Hai-Feng
AU - Sun, Gui-Bo
AU - Yang, Jun-Shan
PY - 2017
DA - 2017/09/11
PB - Pharmaceutical Society of Korea
SP - 1117-1130
IS - 12
VL - 41
PMID - 28895057
SN - 0253-6269
SN - 1976-3786
ER -
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@article{2017_Zhu,
author = {Yin Di Zhu and Jing-Yi Hong and Feng Da Bao and Na Xing and Ling Tian Wang and Zhong Hao Sun and Yun Luo and Hai Jiang and Xu-Dong Xu and Nai Liang Zhu and Hai-Feng Wu and Gui-Bo Sun and Jun-Shan Yang},
title = {Triterpenoid saponins from Clinopodium chinense (Benth.) O. Kuntze and their biological activity},
journal = {Archives of Pharmacal Research},
year = {2017},
volume = {41},
publisher = {Pharmaceutical Society of Korea},
month = {sep},
url = {https://doi.org/10.1007/s12272-017-0943-9},
number = {12},
pages = {1117--1130},
doi = {10.1007/s12272-017-0943-9}
}
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MLA
Скопировать
Zhu, Yin Di, et al. “Triterpenoid saponins from Clinopodium chinense (Benth.) O. Kuntze and their biological activity.” Archives of Pharmacal Research, vol. 41, no. 12, Sep. 2017, pp. 1117-1130. https://doi.org/10.1007/s12272-017-0943-9.