Nano Research

, volume 12 , issue 4 , pages 749-757

Infrared fluorescence imaging of infarcted hearts with Ag2S nanodots

Dirk H Ortgies ^{1, 2}

Ángel Luis García-Villalón ³

Miriam Granado ³

Sara Amor ³

Emma Martín Rodríguez ^{1, 4}

Harrisson D A Santos ^{2, 5}

Jingke Yao ²

Jorge Rubio Retama ⁶

Daniel Jaque ^{1, 2}

Hide authors affiliations Show authors affiliations: 6 affiliations

Nanobiology Group, Instituto Ramón y Cajal de Investigación Sanitaria, IRYCIS, Madrid, Spain |

Fluorescence Imaging Group, Departamento de Física de Materiales – Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid, Spain |

Fluorescence Imaging Group, Departamento de Fisiología – Facultad de Medicina, Avda. Arzobispo Morcillo 2, Universidad Autónoma de Madrid, Madrid, Spain |

⁴

Fluorescence Imaging Group, Departamento de Física Aplicada – Facultad de Ciencias, Universidad Autonoma de Madrid, Madrid, Spain |

⁵

Grupo de Nano-Fotônica e Imagens, Instituto de Física, Universidade Federal de Alagoas, Maceió, Brazil |

⁶

Departamento de Química Física en Ciencias Farmacéuticas, Facultad de Farmacia, Plaza de Ramón y Cajal, s/n, Universidad Complutense de Madrid, Madrid, Spain |

Publication type: Journal Article

Publication date: 2019-01-16

Springer Nature

Nano Research

scimago Q1

wos Q1

SJR: 2.367

CiteScore: 17.1

Impact factor: 9.0

ISSN: 19980124, 19980000

DOI: 10.1007/s12274-019-2280-4

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Atomic and Molecular Physics, and Optics

Condensed Matter Physics

General Materials Science

Electrical and Electronic Engineering

Abstract

Ag2S nanodots have already been demonstrated as promising near-infrared (NIR-II, 1.0–1.45 μm) emitting nanoprobes with low toxicity, high penetration and high resolution for in vivo imaging of, for example, tumors and vasculature. In this work, we have systematically investigated the potential application of functionalized Ag2S nanodots for accurate imaging of damaged myocardium tissues after a myocardial infarction induced by either partial or global ischemia. Ag2S nanodots surface-functionalized with the angiotensin II peptide (ATII) have shown over 10-fold enhanced binding efficiency to damaged tissues than non-specifically (PEG) functionalized Ag2S nanodots due to their interaction with the upregulated angiotensin II receptor type I (AT1R). It is demonstrated how the NIR-II images generated by ATII-functionalized Ag2S nanodots contain valuable information about the location and extension of damaged tissue in the myocardium allowing for a proper identification of the occluded artery as well as an indirect evaluation of the damage level. The potential application of Ag2S nanodots in the near future for in vivo imaging of myocardial infarction was also corroborated by performing proof of concept whole body imaging experiments.

Found

1 citation

Naumov Andrei

🥼

DSc in Physics and Mathematics, associate professor, associate member of the Russian Academy of Sciences

136 publications, 1 737 citations, 6 reviews

h-index: 24

P.N. Lebedev Physical Institute of the Russian Academy of Sciences

Institute of Spectroscopy of the Russian Academy of Sciences

Moscow Pedagogical State University

Research interests

Atomic force microscopy

Fluorescence nanoscopy

Single-molecule spectroscopy

Spectroscopy

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GOST Copy

Ortgies D. H. et al. Infrared fluorescence imaging of infarcted hearts with Ag2S nanodots // Nano Research. 2019. Vol. 12. No. 4. pp. 749-757.

GOST all authors (up to 50) Copy

Ortgies D. H., García-Villalón Á. L., Granado M., Amor S., Rodríguez E. M., Santos H. D. A., Yao J., Rubio Retama J., Jaque D. Infrared fluorescence imaging of infarcted hearts with Ag2S nanodots // Nano Research. 2019. Vol. 12. No. 4. pp. 749-757.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1007/s12274-019-2280-4

UR - https://doi.org/10.1007/s12274-019-2280-4

TI - Infrared fluorescence imaging of infarcted hearts with Ag2S nanodots

T2 - Nano Research

AU - Ortgies, Dirk H

AU - García-Villalón, Ángel Luis

AU - Granado, Miriam

AU - Amor, Sara

AU - Rodríguez, Emma Martín

AU - Santos, Harrisson D A

AU - Yao, Jingke

AU - Rubio Retama, Jorge

AU - Jaque, Daniel

PY - 2019

DA - 2019/01/16

PB - Springer Nature

SP - 749-757

IS - 4

VL - 12

SN - 1998-0124

SN - 1998-0000

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2019_Ortgies,

author = {Dirk H Ortgies and Ángel Luis García-Villalón and Miriam Granado and Sara Amor and Emma Martín Rodríguez and Harrisson D A Santos and Jingke Yao and Jorge Rubio Retama and Daniel Jaque},

title = {Infrared fluorescence imaging of infarcted hearts with Ag2S nanodots},

journal = {Nano Research},

year = {2019},

volume = {12},

publisher = {Springer Nature},

month = {jan},

url = {https://doi.org/10.1007/s12274-019-2280-4},

number = {4},

pages = {749--757},

doi = {10.1007/s12274-019-2280-4}

}

MLA

Cite this

MLA Copy

Ortgies, Dirk H., et al. “Infrared fluorescence imaging of infarcted hearts with Ag2S nanodots.” Nano Research, vol. 12, no. 4, Jan. 2019, pp. 749-757. https://doi.org/10.1007/s12274-019-2280-4.

Publisher

Springer Nature

Journal

Nano Research

scimago Q1

wos Q1

SJR

2.367

CiteScore

17.1

Impact factor

9.0

ISSN

19980124 (Print)

19980000 (Electronic)