Nano Research, volume 12, issue 4, pages 749-757
Infrared fluorescence imaging of infarcted hearts with Ag2S nanodots
Dirk H Ortgies
1, 2
,
Ángel Luis García-Villalón
3
,
Miriam Granado
3
,
Sara Amor
3
,
Emma Martín Rodríguez
1, 4
,
Harrisson D A Santos
2, 5
,
Jingke Yao
2
,
Jorge Rubio Retama
6
,
Daniel Jaque
1, 2
5
Grupo de Nano-Fotônica e Imagens, Instituto de Física, Universidade Federal de Alagoas, Maceió, Brazil
|
Publication type: Journal Article
Publication date: 2019-01-16
Atomic and Molecular Physics, and Optics
Condensed Matter Physics
General Materials Science
Electrical and Electronic Engineering
Abstract
Ag2S nanodots have already been demonstrated as promising near-infrared (NIR-II, 1.0–1.45 μm) emitting nanoprobes with low toxicity, high penetration and high resolution for in vivo imaging of, for example, tumors and vasculature. In this work, we have systematically investigated the potential application of functionalized Ag2S nanodots for accurate imaging of damaged myocardium tissues after a myocardial infarction induced by either partial or global ischemia. Ag2S nanodots surface-functionalized with the angiotensin II peptide (ATII) have shown over 10-fold enhanced binding efficiency to damaged tissues than non-specifically (PEG) functionalized Ag2S nanodots due to their interaction with the upregulated angiotensin II receptor type I (AT1R). It is demonstrated how the NIR-II images generated by ATII-functionalized Ag2S nanodots contain valuable information about the location and extension of damaged tissue in the myocardium allowing for a proper identification of the occluded artery as well as an indirect evaluation of the damage level. The potential application of Ag2S nanodots in the near future for in vivo imaging of myocardial infarction was also corroborated by performing proof of concept whole body imaging experiments.
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Ortgies D. H. et al. Infrared fluorescence imaging of infarcted hearts with Ag2S nanodots // Nano Research. 2019. Vol. 12. No. 4. pp. 749-757.
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Ortgies D. H., García-Villalón Á. L., Granado M., Amor S., Rodríguez E. M., Santos H. D. A., Yao J., Rubio Retama J., Jaque D. Infrared fluorescence imaging of infarcted hearts with Ag2S nanodots // Nano Research. 2019. Vol. 12. No. 4. pp. 749-757.
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TY - JOUR
DO - 10.1007/s12274-019-2280-4
UR - https://doi.org/10.1007/s12274-019-2280-4
TI - Infrared fluorescence imaging of infarcted hearts with Ag2S nanodots
T2 - Nano Research
AU - Ortgies, Dirk H
AU - García-Villalón, Ángel Luis
AU - Granado, Miriam
AU - Amor, Sara
AU - Rodríguez, Emma Martín
AU - Santos, Harrisson D A
AU - Yao, Jingke
AU - Rubio Retama, Jorge
AU - Jaque, Daniel
PY - 2019
DA - 2019/01/16
PB - Springer Nature
SP - 749-757
IS - 4
VL - 12
SN - 1998-0124
SN - 1998-0000
ER -
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@article{2019_Ortgies,
author = {Dirk H Ortgies and Ángel Luis García-Villalón and Miriam Granado and Sara Amor and Emma Martín Rodríguez and Harrisson D A Santos and Jingke Yao and Jorge Rubio Retama and Daniel Jaque},
title = {Infrared fluorescence imaging of infarcted hearts with Ag2S nanodots},
journal = {Nano Research},
year = {2019},
volume = {12},
publisher = {Springer Nature},
month = {jan},
url = {https://doi.org/10.1007/s12274-019-2280-4},
number = {4},
pages = {749--757},
doi = {10.1007/s12274-019-2280-4}
}
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Ortgies, Dirk H., et al. “Infrared fluorescence imaging of infarcted hearts with Ag2S nanodots.” Nano Research, vol. 12, no. 4, Jan. 2019, pp. 749-757. https://doi.org/10.1007/s12274-019-2280-4.