Open Access
Histone demethylase KDM2A promotes tumor cell growth and migration in gastric cancer
Тип публикации: Journal Article
Дата публикации: 2014-09-23
SCImago Q2
БС1
SJR: 0.802
CiteScore: 4.2
Impact factor: —
ISSN: 10104283, 14230380
PubMed ID:
25245333
General Medicine
Краткое описание
Histone demethylase KDM2A has been reported to be dysregulated in lung cancer. However, its function in gastric cancer remains poorly understood. Here, it was found that the expression level of KDM2A was increased in gastric cancer tissues. Moreover, forced expression of KDM2A in gastric cancer cells promoted cell growth and migration, while the knockdown expression of KDM2A inhibited the tumorigenicity of gastric cancer cells. Mechanistically, KDM2A regulated the growth and motility of gastric cancer cells through downregulating the expression of programmed cell death 4 (PDCD4), a known tumor suppressor in the progression of gastric cancer. Taken together, our study suggested that upregulation of KDM2A was very important in the progression of gastric cancer, and KDM2A might be a promising therapeutic target.
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Метрики
55
Всего цитирований:
55
Цитирований c 2025:
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(5.46%)
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ГОСТ |
RIS |
BibTex |
MLA
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ГОСТ
Скопировать
Huang Y. et al. Histone demethylase KDM2A promotes tumor cell growth and migration in gastric cancer // Tumor Biology. 2014. Vol. 36. No. 1. pp. 271-278.
ГОСТ со всеми авторами (до 50)
Скопировать
Huang Y., Liu Y., Yu L., Chen J., Hou J., Cui L., Ma D., Lu W. Histone demethylase KDM2A promotes tumor cell growth and migration in gastric cancer // Tumor Biology. 2014. Vol. 36. No. 1. pp. 271-278.
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RIS
Скопировать
TY - JOUR
DO - 10.1007/s13277-014-2630-5
UR - https://doi.org/10.1007/s13277-014-2630-5
TI - Histone demethylase KDM2A promotes tumor cell growth and migration in gastric cancer
T2 - Tumor Biology
AU - Huang, Yufeng
AU - Liu, Yiqian
AU - Yu, Lijiang
AU - Chen, Jing
AU - Hou, Juan
AU - Cui, Lihua
AU - Ma, De
AU - Lu, Wangkun
PY - 2014
DA - 2014/09/23
PB - SAGE
SP - 271-278
IS - 1
VL - 36
PMID - 25245333
SN - 1010-4283
SN - 1423-0380
ER -
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BibTex (до 50 авторов)
Скопировать
@article{2014_Huang,
author = {Yufeng Huang and Yiqian Liu and Lijiang Yu and Jing Chen and Juan Hou and Lihua Cui and De Ma and Wangkun Lu},
title = {Histone demethylase KDM2A promotes tumor cell growth and migration in gastric cancer},
journal = {Tumor Biology},
year = {2014},
volume = {36},
publisher = {SAGE},
month = {sep},
url = {https://doi.org/10.1007/s13277-014-2630-5},
number = {1},
pages = {271--278},
doi = {10.1007/s13277-014-2630-5}
}
Цитировать
MLA
Скопировать
Huang, Yufeng, et al. “Histone demethylase KDM2A promotes tumor cell growth and migration in gastric cancer.” Tumor Biology, vol. 36, no. 1, Sep. 2014, pp. 271-278. https://doi.org/10.1007/s13277-014-2630-5.
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