Dissolving microneedle rollers for rapid transdermal drug delivery
Xiao-Peng Zhang
1
,
Bao-Li Zhang
1
,
Bo Zhi Chen
1
,
Ze Qiang Zhao
1
,
Wen-Min Fei
2, 3
,
Yong Cui
2, 3
,
Xin Dong Guo
1
Publication type: Journal Article
Publication date: 2021-11-06
scimago Q1
wos Q1
SJR: 1.175
CiteScore: 12.7
Impact factor: 5.5
ISSN: 2190393X, 21903948
PubMed ID:
34743303
Pharmaceutical Science
Abstract
Dissolving microneedle patch (DMNP) is a minimally invasive and painless self-administration device. However, due to skin deformation, it is difficult to apply it on the large areas of skin or curved skin as the patch size increased for DMNP. Here, we propose a polyvinyl alcohol (PVA)–based dissolving microneedle roller (DMNR) device that can be used for delivering drugs rapidly on the large surface areas or curved skin and does not need to be attached on the skin all the time during drug delivery. The hypoglycemic effect of insulin-loaded DMNRs for transdermal delivery of insulin was studied on the type 1 diabetic rat models. It was found that the insulin-loaded DMNR has an immediate and effective hypoglycemic effect that the blood glucose level reduced below to 50% of original blood glucose at 1 h after DMNRs administrated.
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Total citations:
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Citations from 2024:
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(70%)
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BibTex |
MLA
Cite this
GOST
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Zhang X. et al. Dissolving microneedle rollers for rapid transdermal drug delivery // Drug Delivery and Translational Research. 2021. Vol. 12. No. 2. pp. 459-471.
GOST all authors (up to 50)
Copy
Zhang X., Zhang B., Chen B. Z., Zhao Z. Q., Fei W., Cui Y., Guo X. D. Dissolving microneedle rollers for rapid transdermal drug delivery // Drug Delivery and Translational Research. 2021. Vol. 12. No. 2. pp. 459-471.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1007/s13346-021-01048-8
UR - https://doi.org/10.1007/s13346-021-01048-8
TI - Dissolving microneedle rollers for rapid transdermal drug delivery
T2 - Drug Delivery and Translational Research
AU - Zhang, Xiao-Peng
AU - Zhang, Bao-Li
AU - Chen, Bo Zhi
AU - Zhao, Ze Qiang
AU - Fei, Wen-Min
AU - Cui, Yong
AU - Guo, Xin Dong
PY - 2021
DA - 2021/11/06
PB - Springer Nature
SP - 459-471
IS - 2
VL - 12
PMID - 34743303
SN - 2190-393X
SN - 2190-3948
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2021_Zhang,
author = {Xiao-Peng Zhang and Bao-Li Zhang and Bo Zhi Chen and Ze Qiang Zhao and Wen-Min Fei and Yong Cui and Xin Dong Guo},
title = {Dissolving microneedle rollers for rapid transdermal drug delivery},
journal = {Drug Delivery and Translational Research},
year = {2021},
volume = {12},
publisher = {Springer Nature},
month = {nov},
url = {https://doi.org/10.1007/s13346-021-01048-8},
number = {2},
pages = {459--471},
doi = {10.1007/s13346-021-01048-8}
}
Cite this
MLA
Copy
Zhang, Xiao-Peng, et al. “Dissolving microneedle rollers for rapid transdermal drug delivery.” Drug Delivery and Translational Research, vol. 12, no. 2, Nov. 2021, pp. 459-471. https://doi.org/10.1007/s13346-021-01048-8.