Springer Nature
Current Ophthalmology Reports
,  volume 12 ,  issue 2 ,  pages 23-29

Traumatic Optic Neuropathy: Challenges and Opportunities in Developing Neuroprotective and Neuroregenerative Therapies

Publication type: Journal Article
Publication date: 2024-04-30
Springer Nature
scimago Q3
wos Q4
SJR: 0.426
CiteScore: 2.0
Impact factor: 0.8
ISSN: 21674868
Abstract
Purpose of Review

Traumatic optic neuropathy (TON) is a devasting disorder that can result in irreversible vision loss. Understanding the current research to promote neuroprotection and neuroregeneration of the optic nerve after injury may shed light on promising therapeutic avenues.

Recent Findings

With evolving methods to model traumatic optic neuropathy, recent work manipulating signal transduction and cell damage response pathways reveals new clinical opportunities for patients with traumatic injury to the optic nerve.

Summary

Despite years of basic science and clinical research, no treatment for TON exists. The absence of therapies highlights the importance of a comprehensive understanding of molecular pathways involved in retinal ganglion cell survival. Promising therapeutic opportunities may arise from a multi-pronged approach, targeting multiple pathways simultaneously in this complex disease.

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GOST |
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GOST Copy
Tsai N. Y. et al. Traumatic Optic Neuropathy: Challenges and Opportunities in Developing Neuroprotective and Neuroregenerative Therapies // Current Ophthalmology Reports. 2024. Vol. 12. No. 2. pp. 23-29.
GOST all authors (up to 50) Copy
Tsai N. Y., Gallo R. A., Pelaez D., Tse D. T., Kinde B. Traumatic Optic Neuropathy: Challenges and Opportunities in Developing Neuroprotective and Neuroregenerative Therapies // Current Ophthalmology Reports. 2024. Vol. 12. No. 2. pp. 23-29.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1007/s40135-024-00323-4
UR - https://link.springer.com/10.1007/s40135-024-00323-4
TI - Traumatic Optic Neuropathy: Challenges and Opportunities in Developing Neuroprotective and Neuroregenerative Therapies
T2 - Current Ophthalmology Reports
AU - Tsai, Nicole Y
AU - Gallo, Ryan A
AU - Pelaez, Daniel
AU - Tse, David T.
AU - Kinde, Benyam
PY - 2024
DA - 2024/04/30
PB - Springer Nature
SP - 23-29
IS - 2
VL - 12
SN - 2167-4868
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2024_Tsai,
author = {Nicole Y Tsai and Ryan A Gallo and Daniel Pelaez and David T. Tse and Benyam Kinde},
title = {Traumatic Optic Neuropathy: Challenges and Opportunities in Developing Neuroprotective and Neuroregenerative Therapies},
journal = {Current Ophthalmology Reports},
year = {2024},
volume = {12},
publisher = {Springer Nature},
month = {apr},
url = {https://link.springer.com/10.1007/s40135-024-00323-4},
number = {2},
pages = {23--29},
doi = {10.1007/s40135-024-00323-4}
}
MLA
Cite this
MLA Copy
Tsai, Nicole Y., et al. “Traumatic Optic Neuropathy: Challenges and Opportunities in Developing Neuroprotective and Neuroregenerative Therapies.” Current Ophthalmology Reports, vol. 12, no. 2, Apr. 2024, pp. 23-29. https://link.springer.com/10.1007/s40135-024-00323-4.