Therapeutic Potential and Mechanisms of Berberine in Cardiovascular Disease
Publication type: Journal Article
Publication date: 2016-09-15
scimago Q3
wos Q3
SJR: 0.441
CiteScore: 4.9
Impact factor: 2.2
ISSN: 2198641X
Drug Discovery
Biochemistry
Pharmacology
Genetics
Abstract
Berberine is originally isolated from extracts of the Chinese herb Coptis chinensis. It was initially used to treat diarrhea. Over the past two decades, berberine has been shown to be effective for improving glycemic and lipid profiles. Interest in its protective effects against diabetes and cardiovascular risk is beginning to emerge, and research investigating the pharmacological activity of berberine is developing rapidly and being reported internationally. Some clinical evidence has demonstrated the ability of berberine to prevent endothelial dysfunction, myocardial infarction, and arrhythmia in patients with cardiovascular risks. Numerous molecular targets of berberine have been explored, including adenosine monophosphate-activated protein kinase (AMPK), phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT), and NADPH oxidase (NOX). The aim of this review is to focus on the therapeutic potential of berberine in cardiovascular disease and to describe its underlying mechanisms in the pathogenesis of artherosclerosis, hypertension, heart failure, ischemia reperfusion heart injury, stroke, and arrhythmias.
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Total citations:
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MLA
Cite this
GOST
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Zhang M. et al. Therapeutic Potential and Mechanisms of Berberine in Cardiovascular Disease // Current Pharmacology Reports. 2016. Vol. 2. No. 6. pp. 281-292.
GOST all authors (up to 50)
Copy
Zhang M., Feng L., Li J., Chen L. Therapeutic Potential and Mechanisms of Berberine in Cardiovascular Disease // Current Pharmacology Reports. 2016. Vol. 2. No. 6. pp. 281-292.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1007/s40495-016-0070-1
UR - https://doi.org/10.1007/s40495-016-0070-1
TI - Therapeutic Potential and Mechanisms of Berberine in Cardiovascular Disease
T2 - Current Pharmacology Reports
AU - Zhang, Ming
AU - Feng, Linjing
AU - Li, Junnan
AU - Chen, Li
PY - 2016
DA - 2016/09/15
PB - Springer Nature
SP - 281-292
IS - 6
VL - 2
SN - 2198-641X
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2016_Zhang,
author = {Ming Zhang and Linjing Feng and Junnan Li and Li Chen},
title = {Therapeutic Potential and Mechanisms of Berberine in Cardiovascular Disease},
journal = {Current Pharmacology Reports},
year = {2016},
volume = {2},
publisher = {Springer Nature},
month = {sep},
url = {https://doi.org/10.1007/s40495-016-0070-1},
number = {6},
pages = {281--292},
doi = {10.1007/s40495-016-0070-1}
}
Cite this
MLA
Copy
Zhang, Ming, et al. “Therapeutic Potential and Mechanisms of Berberine in Cardiovascular Disease.” Current Pharmacology Reports, vol. 2, no. 6, Sep. 2016, pp. 281-292. https://doi.org/10.1007/s40495-016-0070-1.