Therapeutic Potential and Mechanisms of Berberine in Cardiovascular Disease
Тип публикации: Journal Article
Дата публикации: 2016-09-15
scimago Q3
wos Q3
БС1
SJR: 0.441
CiteScore: 4.9
Impact factor: 2.2
ISSN: 2198641X
Drug Discovery
Biochemistry
Pharmacology
Genetics
Краткое описание
Berberine is originally isolated from extracts of the Chinese herb Coptis chinensis. It was initially used to treat diarrhea. Over the past two decades, berberine has been shown to be effective for improving glycemic and lipid profiles. Interest in its protective effects against diabetes and cardiovascular risk is beginning to emerge, and research investigating the pharmacological activity of berberine is developing rapidly and being reported internationally. Some clinical evidence has demonstrated the ability of berberine to prevent endothelial dysfunction, myocardial infarction, and arrhythmia in patients with cardiovascular risks. Numerous molecular targets of berberine have been explored, including adenosine monophosphate-activated protein kinase (AMPK), phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT), and NADPH oxidase (NOX). The aim of this review is to focus on the therapeutic potential of berberine in cardiovascular disease and to describe its underlying mechanisms in the pathogenesis of artherosclerosis, hypertension, heart failure, ischemia reperfusion heart injury, stroke, and arrhythmias.
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ГОСТ
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Zhang M. et al. Therapeutic Potential and Mechanisms of Berberine in Cardiovascular Disease // Current Pharmacology Reports. 2016. Vol. 2. No. 6. pp. 281-292.
ГОСТ со всеми авторами (до 50)
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Zhang M., Feng L., Li J., Chen L. Therapeutic Potential and Mechanisms of Berberine in Cardiovascular Disease // Current Pharmacology Reports. 2016. Vol. 2. No. 6. pp. 281-292.
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TY - JOUR
DO - 10.1007/s40495-016-0070-1
UR - https://doi.org/10.1007/s40495-016-0070-1
TI - Therapeutic Potential and Mechanisms of Berberine in Cardiovascular Disease
T2 - Current Pharmacology Reports
AU - Zhang, Ming
AU - Feng, Linjing
AU - Li, Junnan
AU - Chen, Li
PY - 2016
DA - 2016/09/15
PB - Springer Nature
SP - 281-292
IS - 6
VL - 2
SN - 2198-641X
ER -
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BibTex (до 50 авторов)
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@article{2016_Zhang,
author = {Ming Zhang and Linjing Feng and Junnan Li and Li Chen},
title = {Therapeutic Potential and Mechanisms of Berberine in Cardiovascular Disease},
journal = {Current Pharmacology Reports},
year = {2016},
volume = {2},
publisher = {Springer Nature},
month = {sep},
url = {https://doi.org/10.1007/s40495-016-0070-1},
number = {6},
pages = {281--292},
doi = {10.1007/s40495-016-0070-1}
}
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MLA
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Zhang, Ming, et al. “Therapeutic Potential and Mechanisms of Berberine in Cardiovascular Disease.” Current Pharmacology Reports, vol. 2, no. 6, Sep. 2016, pp. 281-292. https://doi.org/10.1007/s40495-016-0070-1.