Springer Nature
Blood Research
,  volume 59 ,  issue 1 ,  publication number 46

RAD51 and RAD50 genetic polymorphisms from homologous recombination repair pathway are associated with disease outcomes and organ toxicities in AML

Publication type: Journal Article
Publication date: 2024-12-30
Springer Nature
scimago Q2
wos Q2
SJR: 0.650
CiteScore: 4.1
Impact factor: 2.8
ISSN: 2287979X, 22880011
Abstract
Background

Acute myeloid leukemia (AML) is a heterogeneous malignancy that responds to various therapies. The sensitivity of leukemia cells to chemotherapy is affected by the DNA damage response (DDR). In this study, we examined the association between RAD51 rs1801320, XRCC3 rs861539, NBS1 rs1805794, MRE11 rs569143, and RAD50 rs2299014 variants of the homologous recombination repair (HRR) pathway and AML outcomes.

Material and methods

PCR–RFLP was applied for the genotyping of 67 newly diagnosed cases. We performed Sanger sequencing to confirm the results of RFLP genotyping. Outcomes and organ toxicities were collected and χ2 testing was performed for association analysis.

Results

RAD50 variant allele carriers were protected from renal and hepatic toxicities (p = 0.024 and p = 0.045, respectively), and were associated with resistant disease (p = 0.001). RAD51 variant alleles were protected from liver toxicity (p = 0.031) and correlated with disease resistance (p = 0.012).

Conclusion

RAD50 rs2299014 and RAD51 rs1801320 polymorphisms may be useful for drug adjustment in AML.

Found 

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Mohseni A. et al. RAD51 and RAD50 genetic polymorphisms from homologous recombination repair pathway are associated with disease outcomes and organ toxicities in AML // Blood Research. 2024. Vol. 59. No. 1. 46
GOST all authors (up to 50) Copy
Mohseni A., Toogeh G., Rostami S., Faranoush M., Sharifi M. J. RAD51 and RAD50 genetic polymorphisms from homologous recombination repair pathway are associated with disease outcomes and organ toxicities in AML // Blood Research. 2024. Vol. 59. No. 1. 46
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RIS Copy
TY - JOUR
DO - 10.1007/s44313-024-00033-7
UR - https://link.springer.com/10.1007/s44313-024-00033-7
TI - RAD51 and RAD50 genetic polymorphisms from homologous recombination repair pathway are associated with disease outcomes and organ toxicities in AML
T2 - Blood Research
AU - Mohseni, Alireza
AU - Toogeh, Gholamreza
AU - Rostami, Shahrbano
AU - Faranoush, Mohammad
AU - Sharifi, Mohammad Jafar
PY - 2024
DA - 2024/12/30
PB - Springer Nature
IS - 1
VL - 59
PMID - 39738991
SN - 2287-979X
SN - 2288-0011
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2024_Mohseni,
author = {Alireza Mohseni and Gholamreza Toogeh and Shahrbano Rostami and Mohammad Faranoush and Mohammad Jafar Sharifi},
title = {RAD51 and RAD50 genetic polymorphisms from homologous recombination repair pathway are associated with disease outcomes and organ toxicities in AML},
journal = {Blood Research},
year = {2024},
volume = {59},
publisher = {Springer Nature},
month = {dec},
url = {https://link.springer.com/10.1007/s44313-024-00033-7},
number = {1},
pages = {46},
doi = {10.1007/s44313-024-00033-7}
}