Detection of new metabolites of trifluridine (F3TdR) using 19F NMR spectroscopy
Publication type: Journal Article
Publication date: 1992-12-01
scimago Q1
wos Q1
SJR: 1.599
CiteScore: 9.4
Impact factor: 5.6
ISSN: 00062952, 18732968
PubMed ID:
1472088
Biochemistry
Pharmacology
Abstract
The metabolism of 5-trifluoromethyl-2'-deoxyuridine (trifluridine, F3TdR) in male BALB/C mice has been studied by 19F NMR spectroscopy. Contrary to previous reports, a number of fluorinated metabolites were observed in urine, whole livers and blood samples taken from mice after i.p. injection of F3TdR. The present study describes the identification of two new metabolites in mouse urine using the 19F NMR technique. The NMR of crude urine showed the presence of F3TdR 5-trifluorothymine (F3T), the newly-identified metabolites, 5-trifluoromethyl-5,6-dihydrouracil (DHF3T) and 5-trifluoromethyl-5,6-dihydroxyracil (DOHF3T), and several new, as yet unidentified fluorinate metabolites. These two new metabolites were characterized by comparison to authentic compounds prepared synthetically from F3T.
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Total citations:
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Citations from 2024:
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GOST
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Tandon M. et al. Detection of new metabolites of trifluridine (F3TdR) using 19F NMR spectroscopy // Biochemical Pharmacology. 1992. Vol. 44. No. 11. pp. 2223-2228.
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Tandon M., Kumar P., Wiebe G., Wiebe L. I. Detection of new metabolites of trifluridine (F3TdR) using 19F NMR spectroscopy // Biochemical Pharmacology. 1992. Vol. 44. No. 11. pp. 2223-2228.
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RIS
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TY - JOUR
DO - 10.1016/0006-2952(92)90350-r
UR - https://doi.org/10.1016/0006-2952(92)90350-r
TI - Detection of new metabolites of trifluridine (F3TdR) using 19F NMR spectroscopy
T2 - Biochemical Pharmacology
AU - Tandon, Manju
AU - Kumar, Piyush
AU - Wiebe, Glenis
AU - Wiebe, L. I
PY - 1992
DA - 1992/12/01
PB - Elsevier
SP - 2223-2228
IS - 11
VL - 44
PMID - 1472088
SN - 0006-2952
SN - 1873-2968
ER -
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BibTex (up to 50 authors)
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@article{1992_Tandon,
author = {Manju Tandon and Piyush Kumar and Glenis Wiebe and L. I Wiebe},
title = {Detection of new metabolites of trifluridine (F3TdR) using 19F NMR spectroscopy},
journal = {Biochemical Pharmacology},
year = {1992},
volume = {44},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016/0006-2952(92)90350-r},
number = {11},
pages = {2223--2228},
doi = {10.1016/0006-2952(92)90350-r}
}
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MLA
Copy
Tandon, Manju, et al. “Detection of new metabolites of trifluridine (F3TdR) using 19F NMR spectroscopy.” Biochemical Pharmacology, vol. 44, no. 11, Dec. 1992, pp. 2223-2228. https://doi.org/10.1016/0006-2952(92)90350-r.