Chemico-Biological Interactions

, volume 34 , issue 2 , pages 239-248

New syntheses of N-(guanosin-8-yl)-4-aminobiphenyl and its 5′-monophosphate

Mei Sie Lee ¹

C. A. King ¹

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Department of Chemical Carcinogenesis, Michigan Cancer Foundation, Detroit, MI U.S.A. |

Publication type: Journal Article

Publication date: 1981-03-01

Elsevier

Chemico-Biological Interactions

scimago Q1

wos Q1

SJR: 1.120

CiteScore: 8.6

Impact factor: 5.4

ISSN: 00092797, 18727786

DOI: 10.1016/0009-2797(81)90135-6

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PubMed ID: 6257408

General Medicine

Toxicology

Abstract

N-Acetoxy-4-trifluoroacetylaminobiphenyl (N-acetoxy-TFAABP) reacted readily with Guo and GMP at neutrality in a one-step fashion to yield N-(guanosin-8-yl)4-aminobiphenyl (Guo-ABP) (I) and N(guanosin-8-yl)-4-aminobiphenyl-5'-monophosphate (GMP-ABP) (II), respectively. GMP-ABP could also be formed in much lower yield from the reaction of N-acetoxy-4-formylaminobiphenyl (N-acetoxy-FABP) with GMP (pH 7.0) under more rigorous conditions. Enzymatic hydrolysis of GMP-ABP with alkaline phosphatase in Tris buffer (pH 8.0) at 37 degrees C yielded Guo-ABP. Guo-ABP showed a brilliant blue fluorescence on exposure to 366 nm UV light and its UV absorption spectrum was identical to that of Guo-ABP prepared by Kriek via a different route. Elemental analysis and nuclear magnetic resonance (NMR) data further confirmed the identity of this compound.

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GOST |

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GOST Copy

Lee M. S., King C. A. New syntheses of N-(guanosin-8-yl)-4-aminobiphenyl and its 5′-monophosphate // Chemico-Biological Interactions. 1981. Vol. 34. No. 2. pp. 239-248.

GOST all authors (up to 50) Copy

Lee M. S., King C. A. New syntheses of N-(guanosin-8-yl)-4-aminobiphenyl and its 5′-monophosphate // Chemico-Biological Interactions. 1981. Vol. 34. No. 2. pp. 239-248.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/0009-2797(81)90135-6

UR - https://doi.org/10.1016/0009-2797(81)90135-6

TI - New syntheses of N-(guanosin-8-yl)-4-aminobiphenyl and its 5′-monophosphate

T2 - Chemico-Biological Interactions

AU - Lee, Mei Sie

AU - King, C. A.

PY - 1981

DA - 1981/03/01

PB - Elsevier

SP - 239-248

IS - 2

VL - 34

PMID - 6257408

SN - 0009-2797

SN - 1872-7786

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{1981_Lee,

author = {Mei Sie Lee and C. A. King},

title = {New syntheses of N-(guanosin-8-yl)-4-aminobiphenyl and its 5′-monophosphate},

journal = {Chemico-Biological Interactions},

year = {1981},

volume = {34},

publisher = {Elsevier},

month = {mar},

url = {https://doi.org/10.1016/0009-2797(81)90135-6},

number = {2},

pages = {239--248},

doi = {10.1016/0009-2797(81)90135-6}

}

MLA

Cite this

MLA Copy

Lee, Mei Sie, and C. A. King. “New syntheses of N-(guanosin-8-yl)-4-aminobiphenyl and its 5′-monophosphate.” Chemico-Biological Interactions, vol. 34, no. 2, Mar. 1981, pp. 239-248. https://doi.org/10.1016/0009-2797(81)90135-6.

Publisher

Elsevier

Journal

Chemico-Biological Interactions

scimago Q1

wos Q1

SJR

1.120

CiteScore

8.6

Impact factor

5.4

ISSN

00092797 (Print)

18727786