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volume 54 issue 6 pages PL69-PL74

9-Cis-retinoyl-β-glucuronide is a major metabolite of 9-Cis-retinoic acid

Publication typeJournal Article
Publication date1994-01-01
scimago Q1
wos Q1
SJR1.315
CiteScore10.9
Impact factor5.1
ISSN00243205, 18790631
General Biochemistry, Genetics and Molecular Biology
General Medicine
General Pharmacology, Toxicology and Pharmaceutics
Abstract
The in vivo metabolism of 9-cis-retinoic acid (9-c-RA), an endogenous ligand of retinoid X receptors (RXRs), which can also bind to retinoic acid receptors (RARs), was examined in pregnant mice and rats following a single oral dose of 100 mg 9-cis- retinaldehyde (9-c-RAL) / kg body weight. 9-Cis-retinoyl-β-glucuronide (9-c-RAG), a metabolite not found in vivo before, was a major metabolite of 9-c-RA in mouse plasma and was also present in all mouse tissues examined as well as in rat plasma. In both species putative oxidation products of retinoic acids and high levels of retinyl esters were found. Concentrations of retinoic acid isomers and retinoyl-β-D-glucuronides in the mouse plasma greatly exceeded those of the rat plasma. The finding of high levels of 9-c-RAG underlines the importance of glucuronidation in the metabolism of retinoids.
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GOST |
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GOST Copy
Sass J., Tzimas G., Nau H. 9-Cis-retinoyl-β-glucuronide is a major metabolite of 9-Cis-retinoic acid // Life Sciences. 1994. Vol. 54. No. 6. p. PL69-PL74.
GOST all authors (up to 50) Copy
Sass J., Tzimas G., Nau H. 9-Cis-retinoyl-β-glucuronide is a major metabolite of 9-Cis-retinoic acid // Life Sciences. 1994. Vol. 54. No. 6. p. PL69-PL74.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1016/0024-3205(94)00703-9
UR - https://doi.org/10.1016/0024-3205(94)00703-9
TI - 9-Cis-retinoyl-β-glucuronide is a major metabolite of 9-Cis-retinoic acid
T2 - Life Sciences
AU - Sass, Jörn
AU - Tzimas, Georg
AU - Nau, Heinz
PY - 1994
DA - 1994/01/01
PB - Elsevier
SP - PL69-PL74
IS - 6
VL - 54
PMID - 8295481
SN - 0024-3205
SN - 1879-0631
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{1994_Sass,
author = {Jörn Sass and Georg Tzimas and Heinz Nau},
title = {9-Cis-retinoyl-β-glucuronide is a major metabolite of 9-Cis-retinoic acid},
journal = {Life Sciences},
year = {1994},
volume = {54},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/0024-3205(94)00703-9},
number = {6},
pages = {PL69--PL74},
doi = {10.1016/0024-3205(94)00703-9}
}
MLA
Cite this
MLA Copy
Sass, Jörn, et al. “9-Cis-retinoyl-β-glucuronide is a major metabolite of 9-Cis-retinoic acid.” Life Sciences, vol. 54, no. 6, Jan. 1994, pp. PL69-PL74. https://doi.org/10.1016/0024-3205(94)00703-9.