Progress in cytogerontology
1
Bruce Lyon Memorial Research Laboratory, Children's Hospital Medical Center, 51st & Grove Streets, Oakland, California 94609 U.S.A.
|
Publication type: Journal Article
Publication date: 1979-03-01
scimago Q1
wos Q1
SJR: 1.830
CiteScore: 11.4
Impact factor: 5.1
ISSN: 00476374, 18726216
PubMed ID:
379461
Developmental Biology
Aging
Abstract
The finite in vitro lifetime of cultured normal cells is interpreted to be aging at the cellular level. In addition to the inverse relationship between donor age and population doubling potential (PDP), a number of biochemical and physiological increments and decrements occur prior to the cessation of cell division. The reconstruction of replicating normal human cells from the nuclei of "young" cells and the cytoplasm of "old" cells (and the reverse) suggests that the nucleus governs PDP. Several morphological changes were found to occur in late phase III cells held for up to one year in culture. Autoradiography studies show that (1) a cell population may be composed of several subpopulations, each of which is at a different stage in its life history and (2) lipid synthesis is affected much less as cells age than is DNA, RNA and protein synthesis. Changes occurring in the genetic program of individual cells seem to be the most tenable hypothesis to explain fundamental causes of aging.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
3
4
5
6
7
8
|
|
|
Mechanisms of Ageing and Development
8 publications, 24.24%
|
|
|
Moscow University Biological Sciences Bulletin
4 publications, 12.12%
|
|
|
Experimental Cell Research
2 publications, 6.06%
|
|
|
Biophysics (Russian Federation)
1 publication, 3.03%
|
|
|
Russian Journal of General Chemistry
1 publication, 3.03%
|
|
|
Russian Journal of Developmental Biology
1 publication, 3.03%
|
|
|
Advances in Gerontology
1 publication, 3.03%
|
|
|
Bioscience Reports
1 publication, 3.03%
|
|
|
Molecular and Cellular Biochemistry
1 publication, 3.03%
|
|
|
Aging clinical and experimental research
1 publication, 3.03%
|
|
|
Bulletin of Mathematical Biology
1 publication, 3.03%
|
|
|
Experimental Pathology
1 publication, 3.03%
|
|
|
Experimental Eye Research
1 publication, 3.03%
|
|
|
Journal of Neuroimmunology
1 publication, 3.03%
|
|
|
Ageing Research Reviews
1 publication, 3.03%
|
|
|
Electrophoresis
1 publication, 3.03%
|
|
|
Science
1 publication, 3.03%
|
|
|
1
2
3
4
5
6
7
8
|
Publishers
|
2
4
6
8
10
12
14
|
|
|
Elsevier
14 publications, 42.42%
|
|
|
Pleiades Publishing
8 publications, 24.24%
|
|
|
Springer Nature
4 publications, 12.12%
|
|
|
Wiley
1 publication, 3.03%
|
|
|
American Association for the Advancement of Science (AAAS)
1 publication, 3.03%
|
|
|
2
4
6
8
10
12
14
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
33
Total citations:
33
Citations from 2024:
0
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/0047-6374(79)90081-2
UR - https://doi.org/10.1016/0047-6374(79)90081-2
TI - Progress in cytogerontology
T2 - Mechanisms of Ageing and Development
AU - Hayflick, Leonard
PY - 1979
DA - 1979/03/01
PB - Elsevier
SP - 393-408
IS - 5-6
VL - 9
PMID - 379461
SN - 0047-6374
SN - 1872-6216
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1979_Hayflick,
author = {Leonard Hayflick},
title = {Progress in cytogerontology},
journal = {Mechanisms of Ageing and Development},
year = {1979},
volume = {9},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1016/0047-6374(79)90081-2},
number = {5-6},
pages = {393--408},
doi = {10.1016/0047-6374(79)90081-2}
}
Cite this
MLA
Copy
Hayflick, Leonard. “Progress in cytogerontology.” Mechanisms of Ageing and Development, vol. 9, no. 5-6, Mar. 1979, pp. 393-408. https://doi.org/10.1016/0047-6374(79)90081-2.