Histamine analogues: imidazolylalkylguanidines, synthesis and in vitro pharmacology
Publication type: Journal Article
Publication date: 1992-01-01
scimago Q1
wos Q1
SJR: 1.142
CiteScore: 11.3
Impact factor: 5.9
ISSN: 02235234, 17683254
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Abstract
Impromidine analogues characterized by modified side chains connecting the guanidine and imidazole moieties have been prepared and tested for H2-agonistic activity on isolated guinea-pig right atrium and for H1-antagonistic activity on guinea-pig ileum, respectively. 3-(1H-Imidazol-4-yl)propylguanidines with varied cimetidine-like side chain (5a–d) proved to be almost full H2-agonists and 5–70 times more potent than histamine, whereas compounds with β- or γ-methyl branched imidazolylpropyl moiety (5e, 5f, 5h) are only weak partial H2-agonists. Both unsaturated impromidine analogues (5i, 5j) are full H2-agonists, the (Z)-configurated compound 5j being about 4 times more potent than the (E)-configurated derivate 5i.
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Sellier C. et al. Histamine analogues: imidazolylalkylguanidines, synthesis and in vitro pharmacology // European Journal of Medicinal Chemistry. 1992. Vol. 27. No. 1. pp. 27-32.
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Sellier C., Elz S., Buschauer A., SCHUNACK W. Histamine analogues: imidazolylalkylguanidines, synthesis and in vitro pharmacology // European Journal of Medicinal Chemistry. 1992. Vol. 27. No. 1. pp. 27-32.
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TY - JOUR
DO - 10.1016/0223-5234(92)90056-7
UR - https://doi.org/10.1016/0223-5234(92)90056-7
TI - Histamine analogues: imidazolylalkylguanidines, synthesis and in vitro pharmacology
T2 - European Journal of Medicinal Chemistry
AU - Sellier, C.
AU - Elz, Sigurd
AU - Buschauer, Armin
AU - SCHUNACK, W.
PY - 1992
DA - 1992/01/01
PB - Elsevier
SP - 27-32
IS - 1
VL - 27
SN - 0223-5234
SN - 1768-3254
ER -
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@article{1992_Sellier,
author = {C. Sellier and Sigurd Elz and Armin Buschauer and W. SCHUNACK},
title = {Histamine analogues: imidazolylalkylguanidines, synthesis and in vitro pharmacology},
journal = {European Journal of Medicinal Chemistry},
year = {1992},
volume = {27},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/0223-5234(92)90056-7},
number = {1},
pages = {27--32},
doi = {10.1016/0223-5234(92)90056-7}
}
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MLA
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Sellier, C., et al. “Histamine analogues: imidazolylalkylguanidines, synthesis and in vitro pharmacology.” European Journal of Medicinal Chemistry, vol. 27, no. 1, Jan. 1992, pp. 27-32. https://doi.org/10.1016/0223-5234(92)90056-7.