Bioorganic and Medicinal Chemistry Letters

, volume 6 , issue 1 , pages 59-64

Synthesis and NK-2 antagonist effect of 1,6-diphenyl-pyrazolo [3,4-d]-thiazolo[3,2-a]4H-pyrimidin-4-one

Salvatore Guccione ¹

MARIA ASSUNTA MODICA ¹

Jeanette Longmore ²

David A. Shaw ²

Gloria Uccello Barretta ³

Andrea Santagati ¹

M. G. Santagati ¹

Filippo Russo ¹

Hide authors affiliations Show authors affiliations: 3 affiliations

Istituto di Chimica Farmaceutica e Tossicologica (ICFT), Università di Catania, viale Andrea Doria 6, Ed.12 Catania 95125, Italy |

Merck, Sharp and Dohme Research Laboratories (MSDRL), Neuroscience Research Centre, Terlings Park, Harlow Essex CM20 2QR, U.K. |

Centro CNR di Studio delle Macromolecole Stereordinate ed Otticamente Attive (SMSOA), Dipartimento di Chimica e Chimica Industriale, Università di Pisa, Italy |

Publication type: Journal Article

Publication date: 1996-01-01

Elsevier

Bioorganic and Medicinal Chemistry Letters

scimago Q2

wos Q2

SJR: 0.472

CiteScore: 5.1

Impact factor: 2.2

ISSN: 0960894X, 14643405

DOI: 10.1016/0960-894X(95)00558-B

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Organic Chemistry

Drug Discovery

Biochemistry

Molecular Biology

Pharmaceutical Science

Clinical Biochemistry

Molecular Medicine

Abstract

1,6-Diphenyl-pyrazolo[3,4-d]thiazolo[3,2-a]4H-pyrimidin-4-one caused parallel displacement of the dose-response curve to the NK-2 receptor agonist in the guinea pig trachea suggesting it acts as a competitive antagonist. It is not active in the NK-1 and NK-3 receptor binding assays. A Ca ++ channel blocking action at the voltage-operated channels (L-type) was observed. Graphic

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Guccione S. et al. Synthesis and NK-2 antagonist effect of 1,6-diphenyl-pyrazolo [3,4-d]-thiazolo[3,2-a]4H-pyrimidin-4-one // Bioorganic and Medicinal Chemistry Letters. 1996. Vol. 6. No. 1. pp. 59-64.

GOST all authors (up to 50) Copy

Guccione S., MODICA M. A., Longmore J., Shaw D. A., Uccello Barretta G., Santagati A., Santagati M. G., Russo F. Synthesis and NK-2 antagonist effect of 1,6-diphenyl-pyrazolo [3,4-d]-thiazolo[3,2-a]4H-pyrimidin-4-one // Bioorganic and Medicinal Chemistry Letters. 1996. Vol. 6. No. 1. pp. 59-64.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/0960-894X(95)00558-B

UR - https://doi.org/10.1016/0960-894X(95)00558-B

TI - Synthesis and NK-2 antagonist effect of 1,6-diphenyl-pyrazolo [3,4-d]-thiazolo[3,2-a]4H-pyrimidin-4-one

T2 - Bioorganic and Medicinal Chemistry Letters

AU - Guccione, Salvatore

AU - MODICA, MARIA ASSUNTA

AU - Longmore, Jeanette

AU - Shaw, David A.

AU - Uccello Barretta, Gloria

AU - Santagati, Andrea

AU - Santagati, M. G.

AU - Russo, Filippo

PY - 1996

DA - 1996/01/01

PB - Elsevier

SP - 59-64

IS - 1

VL - 6

SN - 0960-894X

SN - 1464-3405

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{1996_Guccione,

author = {Salvatore Guccione and MARIA ASSUNTA MODICA and Jeanette Longmore and David A. Shaw and Gloria Uccello Barretta and Andrea Santagati and M. G. Santagati and Filippo Russo},

title = {Synthesis and NK-2 antagonist effect of 1,6-diphenyl-pyrazolo [3,4-d]-thiazolo[3,2-a]4H-pyrimidin-4-one},

journal = {Bioorganic and Medicinal Chemistry Letters},

year = {1996},

volume = {6},

publisher = {Elsevier},

month = {jan},

url = {https://doi.org/10.1016/0960-894X(95)00558-B},

number = {1},

pages = {59--64},

doi = {10.1016/0960-894X(95)00558-B}

}

MLA

Cite this

MLA Copy

Guccione, Salvatore, et al. “Synthesis and NK-2 antagonist effect of 1,6-diphenyl-pyrazolo [3,4-d]-thiazolo[3,2-a]4H-pyrimidin-4-one.” Bioorganic and Medicinal Chemistry Letters, vol. 6, no. 1, Jan. 1996, pp. 59-64. https://doi.org/10.1016/0960-894X(95)00558-B.

Publisher

Elsevier

Journal

Bioorganic and Medicinal Chemistry Letters

scimago Q2

wos Q2

SJR

0.472

CiteScore

5.1

Impact factor

2.2

ISSN

0960894X (Print)

14643405 (Electronic)