, pages 765-786

Scaffolds for pancreatic tissue engineering

Carlo Gazia ^{1, 2, 3}

Michaela Gaffley ^{1, 3}

Amish Asthana ^{1, 3}

Deborah Chaimov ^{1, 3}

Giuseppe Orlando ^{1, 3}

Hide authors affiliations Show authors affiliations: 3 affiliations

Department of Surgery, Section of Transplantation, Wake Forest School of Medicine, Winston Salem, NC, United States |

Transplant Unit, Tor Vergata University, Rome, Italy |

Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, United States |

Publication type: Book Chapter

Publication date: 2019-06-21

Elsevier

DOI: 10.1016/B978-0-08-102561-1.00032-4

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Abstract

Emerging technologies in regenerative medicine are crucial to overcome the organ donor shortage and the limitations in conventional diabetes treatments. A bioengineered pancreas, obtained through the development of a three-dimensional scaffold from both animal and human extracellular matrix, represents the endeavor to provide alternative therapies to pancreatic transplantation. This alternative hopes to provide the needed components, supply a temporary substrate that enhances cellular function, and aid organized development before implantation. This chapter will present an overview of the different techniques used to engineer scaffolds from natural and synthetic materials. We will discuss their main properties and applications in the regenerative medicine pancreatic research field.

Found

1 citation

Belova Aleksandra

PhD in Biological/biomedical sciences

27 publications, 80 citations

h-index: 5

V.I.Shumakov Federal Research Center of Transplantology and Artificial Organs

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