Molecular Basis of Neurological Disorders

Disorders of the central nervous system are worldwide causes of morbidity and mortality. Neurological disorders pose a large burden on worldwide health. The Global Burden of Disease Study shows that the neurological disorders such as Alzheimer's and other dementias, Parkinson's disease, multiple sclerosis, epilepsy, muscular dystrophy, and headache disorders represent 3% of the worldwide. Neurological disorders are defined as an inappropriate or impaired function of the peripheral or CNS due to impaired electrical impulses throughout the nervous system that may show the heterogeneous symptoms according to the parts of the system, which is involved in these pathologic processes. Some growing evidence on brain inflammation, viral or bacterial infection, and genetic components of neurological disease has been collected during recent years. On the basis of this evidence, we focused on the association of brain inflammation, viral or bacterial infection, mitochondrial gene, and other genetic components or mutations with neurological disorders.