A General Approach to Angucyclines: Synthesis of Hatomarubigin A, Rubiginone B2, Antibiotic X-1488E, 6-Hydroxytetrangulol, and Tetrangulol
Publication type: Journal Article
Publication date: 2000-12-01
scimago Q3
wos Q2
SJR: 0.426
CiteScore: 4.1
Impact factor: 2.2
ISSN: 00404020, 14645416
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
Hatomarubigin A was prepared in 41% yield in a single procedure from acyl naphthoquinone 15 and 5-methylcyclohexane-1,3-dione (16). The net reaction consists of Michael addition to an acyl quinone followed by intramolecular aldol condensation. Hatomarubigin A then served as a common intermediate in syntheses of the angucyclinone antibiotics rubiginone B2, antibiotic X-1488E, 6-hydroxytetrangulol, and tetrangulol.
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GOST
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Parker K. A., Ding Q. A General Approach to Angucyclines: Synthesis of Hatomarubigin A, Rubiginone B2, Antibiotic X-1488E, 6-Hydroxytetrangulol, and Tetrangulol // Tetrahedron. 2000. Vol. 56. No. 52. pp. 10249-10254.
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Parker K. A., Ding Q. A General Approach to Angucyclines: Synthesis of Hatomarubigin A, Rubiginone B2, Antibiotic X-1488E, 6-Hydroxytetrangulol, and Tetrangulol // Tetrahedron. 2000. Vol. 56. No. 52. pp. 10249-10254.
Cite this
RIS
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TY - JOUR
DO - 10.1016/S0040-4020(00)00869-3
UR - https://doi.org/10.1016/S0040-4020(00)00869-3
TI - A General Approach to Angucyclines: Synthesis of Hatomarubigin A, Rubiginone B2, Antibiotic X-1488E, 6-Hydroxytetrangulol, and Tetrangulol
T2 - Tetrahedron
AU - Parker, Kathlyn A
AU - Ding, Qing-jie
PY - 2000
DA - 2000/12/01
PB - Elsevier
SP - 10249-10254
IS - 52
VL - 56
SN - 0040-4020
SN - 1464-5416
ER -
Cite this
BibTex (up to 50 authors)
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@article{2000_Parker,
author = {Kathlyn A Parker and Qing-jie Ding},
title = {A General Approach to Angucyclines: Synthesis of Hatomarubigin A, Rubiginone B2, Antibiotic X-1488E, 6-Hydroxytetrangulol, and Tetrangulol},
journal = {Tetrahedron},
year = {2000},
volume = {56},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016/S0040-4020(00)00869-3},
number = {52},
pages = {10249--10254},
doi = {10.1016/S0040-4020(00)00869-3}
}
Cite this
MLA
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Parker, Kathlyn A., and Qing-jie Ding. “A General Approach to Angucyclines: Synthesis of Hatomarubigin A, Rubiginone B2, Antibiotic X-1488E, 6-Hydroxytetrangulol, and Tetrangulol.” Tetrahedron, vol. 56, no. 52, Dec. 2000, pp. 10249-10254. https://doi.org/10.1016/S0040-4020(00)00869-3.