Tetrahedron Letters, volume 23, issue 10, pages 1023-1026

Synthesis of the sulfones of leukotriene C4, D4, and E4

Yves Girard 1
, 
Marie Larue 1
, 
Thomas K. Thomas A. Jones (2) 1
, 
J. Rokach 1
1
 
Merck Frosst Laboratories, P.O. Box 1005, Pointe-Claire / Dorval Quebec, Canada H9R 4p8 | 
Publication type: Journal Article
Publication date: 1982-01-01
scimago Q3
wos Q3
SJR: 0.323
CiteScore: 3.5
Impact factor: 1.5
ISSN: 00404039, 18733581
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
A simple one-step preparation of the sulfones of Leukotriene C 4 , D 4 and E 4 has been developed by the direct oxidation of the parent compounds. An alternative synthesis of these sulfones has also been carried out by reduction of an acetylenic precursor.
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