Tetrahedron Letters, volume 39, issue 13, pages 1685-1688

Synthesis of hexahydro-1H-pyrrolo[1,2-c]imidazole derivatives by sequential azomethine ylide cycloaddition and urea cyclization reactions

Samir Najdi ^{1, 2}

K J Park ³

Marilyn M. Olmstead ³

Mark J. Kurth ³

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Department of Chemistry Al-Quds University East Jerusalem, Israel |

Department of Chemistry University of California, Davis Davis, California 95616 USA |

Department of Chemistry, University of California, Davis, Davis, California 95616, USA |

Publication type: Journal Article

Publication date: 1998-03-01

Elsevier

Journal: Tetrahedron Letters

scimago Q3

wos Q3

SJR: 0.323

CiteScore: 3.5

Impact factor: 1.5

ISSN: 00404039, 18733581

DOI: 10.1016/S0040-4039(98)00125-7

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Organic Chemistry

Drug Discovery

Biochemistry

Abstract

An efficient, diastereoselective route to 2, 5, 6, 7-tetra-substituted 1H-purrolo[1,2-c]imidazoles has been developed using azomethine ylide cycloaddition and urea cyclization reactions. Relative stereochemical assignments at the four contiguous pyrrolidine stereogenic centers were established by single-crystal X-ray analysis.

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Wiley	Wiley, 5, 38.46% Wiley 5 publications, 38.46%
Elsevier	Elsevier, 4, 30.77% Elsevier 4 publications, 30.77%
American Chemical Society (ACS)	American Chemical Society (ACS), 3, 23.08% American Chemical Society (ACS) 3 publications, 23.08%
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Publisher

Elsevier

Journal

Tetrahedron Letters

scimago Q3

wos Q3

SJR

0.323

CiteScore

3.5

Impact factor

1.5

ISSN

00404039 (Print)

18733581 (Electronic)

Synthesis of hexahydro-1H-pyrrolo[1,2-c]imidazole derivatives by sequential azomethine ylide cycloaddition and urea cyclization reactions

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