The Chemistry of Thienopyridines

Publisher Summary It is noted that the derivatives of pyridine attract significant interest because of their great practical usefulness, primarily, due to their various biological activities. Among pyridine derivatives, the fused analogs are considered extremely important. These factors are supplemented with variations due to annulation at different positions of the heterocyclic fragments. Further, among these heterocyclic systems, thienopyridines occupy a special place. This chapter describes the synthesis, reactivity, and biological activities of isomeric thienopyridines. The chapter considers six isomeric thienopyridine structures characterized by different annulation modes— namely, (1) thieno[2,3- b ]pyridine, (2) thieno[3,2- b ]pyridine, (3) thieno[2,3- c ]pyridine, (4) thieno[3,2- c ]pyridine, (5) thieno[3,4- b ]pyridine, and (6) thieno[3,4- c ]pyridine. The high pharmacological potential of thienopyridine derivatives stimulates the elaboration of new ingenious methods, nonconventional approaches, and regio- and stereoselective procedures that essentially extends the synthetic scope of the chemistry of nitrogen heterocycles. The unexhausted potential of thienopyridine derivatives as synthons also attracts considerable attention of organic chemists, because such compounds allow transformations that have been previously inaccessible.