Archives of Gerontology and Geriatrics, volume 32, issue 3, pages 275-282
Alpha-lipoic acid as a new treatment option for Azheimer type dementia
1
Department of Medical Rehabilitation and Geriatrics, Henriettenstiftung, Schwemannstraße 19, D-30559, Hannover, Germany
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2
Publication type: Journal Article
Publication date: 2001-06-01
scimago Q1
wos Q2
SJR: 1.054
CiteScore: 7.3
Impact factor: 3.5
ISSN: 01674943, 18726976
PubMed ID:
11395173
Geriatrics and Gerontology
Aging
Gerontology
Health (social science)
Abstract
Oxidative stress and energy depletion are characteristic biochemical hallmarks of Alzheimer's disease (AD), thus antioxidants with positive effects on glucose metabolism such as thioctic (alpha-lipoic) acid should exert positive effects in these patients. Therefore, 600 mg alpha-lipoic acid was given daily to nine patients with AD and related dementias (receiving a standard treatment with acetylcholinesterase inhibitors) in an open study over an observation period of, on avarage, 337+/-80 days. The treatment led to a stabilization of cognitive functions in the study group, demonstrated by constant scores in two neuropsychological tests (mini-mental state examination: MMSE and AD assessment scale, cognitive subscale: ADAScog). Despite the fact that this study was small and not randomized, this is the first indication that treatment with alpha-lipoic acid might be a successful 'neuroprotective' therapy option for AD and related dementias.
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Hager K. et al. Alpha-lipoic acid as a new treatment option for Azheimer type dementia // Archives of Gerontology and Geriatrics. 2001. Vol. 32. No. 3. pp. 275-282.
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Hager K., Marahrens A., Kenklies M., Riederer P., M??nch G. Alpha-lipoic acid as a new treatment option for Azheimer type dementia // Archives of Gerontology and Geriatrics. 2001. Vol. 32. No. 3. pp. 275-282.
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TY - JOUR
DO - 10.1016/S0167-4943(01)00104-2
UR - https://doi.org/10.1016/S0167-4943(01)00104-2
TI - Alpha-lipoic acid as a new treatment option for Azheimer type dementia
T2 - Archives of Gerontology and Geriatrics
AU - Hager, Klaus
AU - Marahrens, Andres
AU - Kenklies, Marlene
AU - Riederer, Peter
AU - M??nch, Gerald
PY - 2001
DA - 2001/06/01
PB - Elsevier
SP - 275-282
IS - 3
VL - 32
PMID - 11395173
SN - 0167-4943
SN - 1872-6976
ER -
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@article{2001_Hager,
author = {Klaus Hager and Andres Marahrens and Marlene Kenklies and Peter Riederer and Gerald M??nch},
title = {Alpha-lipoic acid as a new treatment option for Azheimer type dementia},
journal = {Archives of Gerontology and Geriatrics},
year = {2001},
volume = {32},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016/S0167-4943(01)00104-2},
number = {3},
pages = {275--282},
doi = {10.1016/S0167-4943(01)00104-2}
}
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MLA
Copy
Hager, Klaus, et al. “Alpha-lipoic acid as a new treatment option for Azheimer type dementia.” Archives of Gerontology and Geriatrics, vol. 32, no. 3, Jun. 2001, pp. 275-282. https://doi.org/10.1016/S0167-4943(01)00104-2.