Nutrition, volume 16, issue 4, pages 296-302

Hyperhomocysteinemia in chronic alcoholism: relations to folic acid and vitamins b6 and b12 status

Marco A. Cravo 1
Maria E. Camilo 2
1
 
Serviço de Gastrenterologia, Instituto Português de Oncologia Francisco GentilLisbon, Portugal
2
 
Centro de Nutrição e Metabolismo, Faculdade de Medicina de Lisboa, Lisbon, Portugal
Publication typeJournal Article
Publication date2000-04-01
Journal: Nutrition
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor4.4
ISSN08999007, 18731244
Nutrition and Dietetics
Endocrinology, Diabetes and Metabolism
Abstract
The objective of this review is to present and discuss the current perspectives of homocysteine and one carbon metabolism in chronic alcoholism. Chronic alcoholics frequently suffer from specific micronutrient deficiencies, including vitamins involved in one carbon metabolism, i.e., folate, vitamin B(6) and vitamin B(12). The possible link between homocysteine and alcoholism stems from the fact that homocysteine metabolism is closely linked to the metabolism of these three vitamins. In fact, homocysteine stands at the intersection of two pathways: methylation and transsulfuration. In methylation, homocysteine acquires a methyl group from N-5-methyltetrahydrofolate in a vitamin B(12) dependent reaction, whereas in the transsulfuration pathway, homocysteine condenses with serine to form cystathionine in an irreversible reaction catalyzed by the pyridoxal-5'-phosphate-containing enzyme, cystathionine-beta-synthase. Due to these relationships, nutritional deficiency of one of these vitamins, as a consequence of chronic alcohol intake, could lead to metabolic disruption and potentially to hyperhomocysteinemia. Consistent with an interference of alcohol in these metabolic pathways, a previous study performed in chronic alcoholics in whom hyperhomocysteinemia was observed along with disturbed vitamin status, DNA hypomethylation in peripheral lymphocytes was demonstrated as well. Because all these alterations were observed in the absence of clinically overt disease, one might speculate whether these metabolic abnormalities could be involved in the pathogenesis of organic diseases associated to chronic alcoholism.

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GOST Copy
Cravo M. A., Camilo M. E. Hyperhomocysteinemia in chronic alcoholism: relations to folic acid and vitamins b6 and b12 status // Nutrition. 2000. Vol. 16. No. 4. pp. 296-302.
GOST all authors (up to 50) Copy
Cravo M. A., Camilo M. E. Hyperhomocysteinemia in chronic alcoholism: relations to folic acid and vitamins b6 and b12 status // Nutrition. 2000. Vol. 16. No. 4. pp. 296-302.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1016/S0899-9007(99)00297-X
UR - https://doi.org/10.1016/S0899-9007(99)00297-X
TI - Hyperhomocysteinemia in chronic alcoholism: relations to folic acid and vitamins b6 and b12 status
T2 - Nutrition
AU - Cravo, Marco A.
AU - Camilo, Maria E.
PY - 2000
DA - 2000/04/01
PB - Elsevier
SP - 296-302
IS - 4
VL - 16
SN - 0899-9007
SN - 1873-1244
ER -
BibTex |
Cite this
BibTex Copy
@article{2000_Cravo,
author = {Marco A. Cravo and Maria E. Camilo},
title = {Hyperhomocysteinemia in chronic alcoholism: relations to folic acid and vitamins b6 and b12 status},
journal = {Nutrition},
year = {2000},
volume = {16},
publisher = {Elsevier},
month = {apr},
url = {https://doi.org/10.1016/S0899-9007(99)00297-X},
number = {4},
pages = {296--302},
doi = {10.1016/S0899-9007(99)00297-X}
}
MLA
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MLA Copy
Cravo, Marco A., and Maria E. Camilo. “Hyperhomocysteinemia in chronic alcoholism: relations to folic acid and vitamins b6 and b12 status.” Nutrition, vol. 16, no. 4, Apr. 2000, pp. 296-302. https://doi.org/10.1016/S0899-9007(99)00297-X.
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