Beta 3 agonists. Part 1: evolution from inception to BMS-194449
W.N. Washburn
1
,
P.M. Sher
1
,
K.M. Poss
1
,
R.N. Girotra
1
,
P. J. McCann
1
,
A.V. Gavai
1
,
A.B. Mikkilineni
1
,
Arvind Mathur
1
,
P. Cheng
1
,
T.C. Dejneka
1
,
C. Q. Sun
1
,
Tao Wang
1
,
T.W. Harper
1
,
A. Russell
1
,
D.A. Slusarchyk
1
,
S. Skwish
1
,
G. E. Allen
1
,
D.E. Hillyer
1
,
B H Frohlich
1
,
B.E. Abboa-Offei
1
,
M. cap
1
,
T L Waldron
1
,
R. P. George
1
,
B Tesfamariam
1
,
C.P. Ciosek
1
,
D. Ryono
1
,
D. A. Young
1
,
K E Dickinson
1
,
A A Seymour
1
,
Cynthia Arbeeny
1
,
R E Gregg
1
Тип публикации: Journal Article
Дата публикации: 2001-12-01
scimago Q2
wos Q2
БС2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
11714605
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Краткое описание
Screening of the BMS collection identified 4-hydroxy-3-methylsulfonanilidoethanolamines as full beta 3 agonists. Substitution of the ethanolamine nitrogen with a benzyl group bearing a para hydrogen bond acceptor promoted beta(3) selectivity. SAR elucidation established that highly selective beta(3) agonists were generated upon substitution of C(alpha) with either benzyl to form (R)-1,2-diarylethylamines or with aryl to generate 1,1-diarylmethylamines. This latter subset yielded a clinical candidate, BMS-194449 (35).(1)
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Washburn W. et al. Beta 3 agonists. Part 1: evolution from inception to BMS-194449 // Bioorganic and Medicinal Chemistry Letters. 2001. Vol. 11. No. 23. pp. 3035-3039.
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Washburn W., Sher P., Poss K., Girotra R., McCann P. J., Gavai A., Mikkilineni A., Mathur A., Cheng P., Dejneka T., Sun C. Q., Wang T., Harper T., Russell A., Slusarchyk D., Skwish S., Allen G. E., Hillyer D., Frohlich B. H., Abboa-Offei B., cap M., Waldron T. L., George R. P., Tesfamariam B., Ciosek C., Ryono D., Young D. A., Dickinson K. E., Seymour A. A., Arbeeny C., Gregg R. E. Beta 3 agonists. Part 1: evolution from inception to BMS-194449 // Bioorganic and Medicinal Chemistry Letters. 2001. Vol. 11. No. 23. pp. 3035-3039.
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TY - JOUR
DO - 10.1016/S0960-894X(01)00628-X
UR - https://doi.org/10.1016/S0960-894X(01)00628-X
TI - Beta 3 agonists. Part 1: evolution from inception to BMS-194449
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Washburn, W.N.
AU - Sher, P.M.
AU - Poss, K.M.
AU - Girotra, R.N.
AU - McCann, P. J.
AU - Gavai, A.V.
AU - Mikkilineni, A.B.
AU - Mathur, Arvind
AU - Cheng, P.
AU - Dejneka, T.C.
AU - Sun, C. Q.
AU - Wang, Tao
AU - Harper, T.W.
AU - Russell, A.
AU - Slusarchyk, D.A.
AU - Skwish, S.
AU - Allen, G. E.
AU - Hillyer, D.E.
AU - Frohlich, B H
AU - Abboa-Offei, B.E.
AU - cap, M.
AU - Waldron, T L
AU - George, R. P.
AU - Tesfamariam, B
AU - Ciosek, C.P.
AU - Ryono, D.
AU - Young, D. A.
AU - Dickinson, K E
AU - Seymour, A A
AU - Arbeeny, Cynthia
AU - Gregg, R E
PY - 2001
DA - 2001/12/01
PB - Elsevier
SP - 3035-3039
IS - 23
VL - 11
PMID - 11714605
SN - 0960-894X
SN - 1464-3405
ER -
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@article{2001_Washburn,
author = {W.N. Washburn and P.M. Sher and K.M. Poss and R.N. Girotra and P. J. McCann and A.V. Gavai and A.B. Mikkilineni and Arvind Mathur and P. Cheng and T.C. Dejneka and C. Q. Sun and Tao Wang and T.W. Harper and A. Russell and D.A. Slusarchyk and S. Skwish and G. E. Allen and D.E. Hillyer and B H Frohlich and B.E. Abboa-Offei and M. cap and T L Waldron and R. P. George and B Tesfamariam and C.P. Ciosek and D. Ryono and D. A. Young and K E Dickinson and A A Seymour and Cynthia Arbeeny and R E Gregg},
title = {Beta 3 agonists. Part 1: evolution from inception to BMS-194449},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2001},
volume = {11},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016/S0960-894X(01)00628-X},
number = {23},
pages = {3035--3039},
doi = {10.1016/S0960-894X(01)00628-X}
}
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MLA
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Washburn, W.N., et al. “Beta 3 agonists. Part 1: evolution from inception to BMS-194449.” Bioorganic and Medicinal Chemistry Letters, vol. 11, no. 23, Dec. 2001, pp. 3035-3039. https://doi.org/10.1016/S0960-894X(01)00628-X.