6-Iodonordihydrocapsaicin☆

6-Iodonordihydrocapsaicin was first synthesized by Giovanni Appendino at the Department of Chemical, Food, Pharmaceutical and Pharmacological Sciences (DiSCAFF), Novara, Italy, while developing a series of halogenated derivatives of capsaicin. This compound is a potent antagonist at the vanilloid VR-1 (TRPV1) receptor, antagonizes transient receptor potential channels of melastatin type 8 (TRPM8) and act as an agonist at estrogen receptor alpha (ERα). 6-Iodonordihydrocapsaicin has also recently been used in in vivo preclinical studies in order to probe the role of endogenous TRPV1 tone. Administration of 6-Iodonordihydrocapsaicin directly into the rat medial and prefrontal cortex has been shown to reduce anxiety-like behaviour, without modulating exploratory or nociceptive responding.