Neuroinflammation in Multiple Sclerosis

Multiple Sclerosis (MS) is a chronic inflammatory, demyelinating disorder of the central nervous system (CNS) that originates as an autoimmune attack by peripheral immune cells against CNS antigens. Although infiltrating, adaptive immune cells are thought to play major roles in disease initiation and inflammation in early stages of MS, the disease eventually develops into a progressive neurodegenerative disorder involving mainly innate immune mechanisms. Understanding the cellular responses of CNS resident cells to inflammation, ageing, and metabolic dysregulation is pivotal to dissecting their contributions to demyelination, neurodegeneration, and disease progression, as well as tissue repair, remyelination and neuroprotection.