Ribosome binding antibacterial agents

The ribosome constitutes one of the prime targets for antibiotics within a bacterial cell. The existing remedial antibiotics are less effective against bacteria that acquire multidrug resistance. Hence, the discovery of new compounds is imperative to target novel sites within the ribosome. The characterization and optimization of peptide antibiotics that target the ribosome are necessary for the development of novel antimicrobial therapies. There is a variety of scaffolds that exist within the ribosome. Structural and biochemical analyses indicate that multiple binding interactions within the ribosome are required to inhibit the translation process. Targeting the structure that shows the ribosomal binding with the antimicrobial agents helps estimate and design novel drug targets to reduce the risk of multidrug resistance.